Emergency_Contraception_Flashcards
What are the two methods of emergency contraception currently available in the UK?
Emergency hormonal contraception and intrauterine device (IUD).
What are the two methods of emergency hormonal contraception?
Levonorgestrel and ulipristal, a progesterone receptor modulator.
What is the mode of action of levonorgestrel?
Not fully understood - acts both to stop ovulation and inhibit implantation.
When should levonorgestrel be taken?
As soon as possible - efficacy decreases with time. Must be taken within 72 hours of unprotected sexual intercourse (UPSI).
What is the dosage for levonorgestrel?
Single dose of levonorgestrel 1.5mg (a progesterone). The dose should be doubled for those with a BMI >26 or weight over 70kg.
How effective is levonorgestrel when used within 72 hours of UPSI?
84% effective.
What are the side effects of levonorgestrel?
Disturbance of the current menstrual cycle in a significant minority of women. Vomiting occurs in around 1%. If vomiting occurs within 3 hours, the dose should be repeated.
Can levonorgestrel be used more than once in a menstrual cycle?
Yes, if clinically indicated.
When can hormonal contraception be started after using levonorgestrel?
Hormonal contraception can be started immediately after using levonorgestrel (Levonelle) for emergency contraception.
What is the primary mode of action of ulipristal?
Inhibition of ovulation.
What is the dosage for ulipristal?
30mg oral dose taken as soon as possible, no later than 120 hours after intercourse.
Can ulipristal be used concomitantly with levonorgestrel?
No, concomitant use with levonorgestrel is not recommended.
How does ulipristal affect hormonal contraception?
Ulipristal may reduce the effectiveness of hormonal contraception. Contraception with the pill, patch, or ring should be started, or restarted, 5 days after having ulipristal. Barrier methods should be used during this period.
What caution should be exercised with ulipristal?
Caution should be exercised in patients with severe asthma.
Can ulipristal be used more than once in the same menstrual cycle?
Yes, it can be used more than once in the same cycle.
What is the recommendation for breastfeeding after taking ulipristal?
Breastfeeding should be delayed for one week after taking ulipristal. There are no such restrictions on the use of levonorgestrel.
What is the most effective method of emergency contraception?
A copper IUD.
When should a copper IUD be inserted?
Must be inserted within 5 days of UPSI, or if a woman presents after more than 5 days, an IUD may be fitted up to 5 days after the likely ovulation date.
What are the benefits of a copper IUD for emergency contraception?
It may inhibit fertilisation or implantation, is 99% effective regardless of where it is used in the cycle, and may be left in-situ to provide long-term contraception.
What should be done if the patient is considered at high risk of sexually transmitted infection when using a copper IUD?
Prophylactic antibiotics may be given.
summarise
Emergency contraception
There are two methods currently available in the UK:
Emergency hormonal contraception
There are now two methods of emergency hormonal contraception (‘emergency pill’, ‘morning-after pill’); levonorgestrel and ulipristal, a progesterone receptor modulator.
Levonorgestrel
mode of action not fully understood - acts both to stop ovulation and inhibit implantation
should be taken as soon as possible - efficacy decreases with time
must be taken within 72 hours of unprotected sexual intercourse (UPSI)*
single dose of levonorgestrel 1.5mg (a progesterone)
the dose should be doubled for those with a BMI >26 or weight over 70kg
84% effective is used within 72 hours of UPSI
levonorgestrel is safe and well-tolerated. Disturbance of the current menstrual cycle is seen in a significant minority of women. Vomiting occurs in around 1%
if vomiting occurs within 3 hours then the dose should be repeated
can be used more than once in a menstrual cycle if clinically indicated
hormonal contraception can be started immediately after using levornogestrel (Levonelle) for emergency contraception
Ulipristal
a selective progesterone receptor modulator currently marketed as EllaOne. The primary mode of action is thought to be inhibition of ovulation
30mg oral dose taken as soon as possible, no later than 120 hours after intercourse
concomitant use with levonorgestrel is not recommended
Ulipristal may reduce the effectiveness of hormonal contraception. Contraception with the pill, patch or ring should be started, or restarted, 5 days after having ulipristal. Barrier methods should be used during this period
caution should be exercised in patients with severe asthma
repeated dosing within the same menstrual cycle was previously not recommended - however, this has now changed and ulipristal can be used more than once in the same cycle
breastfeeding should be delayed for one week after taking ulipristal. There are no such restrictions on the use of levonorgestrel
Intrauterine device (IUD)
a copper IUD is the most effective method of emergency contraception and should be offered to all women if they meet the criteria
if the criteria for insertion of a copper IUD are not met or is not acceptable to the woman, oral emergency contraception should be considered
in practice the vast majority of women choose oral emergency contraception, but it is important to offer the choice to all women given how effective copper IUDs are
must be inserted within 5 days of UPSI, or
if a woman presents after more than 5 days then an IUD may be fitted up to 5 days after the likely ovulation date
may inhibit fertilisation or implantation
prophylactic antibiotics may be given if the patient is considered to be at high-risk of sexually transmitted infection
is 99% effective regardless of where it is used in the cycle
may be left in-situ to provide long-term contraception. If the client wishes for the IUD to be removed it should be at least kept in until the next period
*may be offered after this period as long as the client is aware of reduced effectiveness and unlicensed indication
An 18-year-old attends her GP the morning after unprotected sexual intercourse (UPSI). She would like emergency contraception to ensure she is not pregnant. A pregnancy test is negative. Which is the most appropriate next step in management?
- Danazol
- Clomiphene
- Combined oral contraceptive pill
- Levonorgestrel
- Advise patient to return in one week to repeat pregnancy test, as it is too soon to see if she is pregnant at present
- Levonorgestrel
Levonorgestrel must be taken within 72 hours of UPSI
A copper intrauterine contraceptive device (copper coil), an oral progesterone-only contraceptive (levonorgestrel) or a selective progesterone receptor modulator (ulipristal acetate) could be offered in the above situation as emergency contraception. These both act to prevent a fertilised ovum being implanted.
Levonorgestrel is licensed for use up to 72 hours after UPSI. Although unlicensed, use between 72-120 hours after UPSI may be considered if other methods of emergency contraception are contraindicated. It can also be used more than once in the same cycle if indicated, although in such cases patients may require referral for education regarding safe sexual practices. 5-5.8% of women will become pregnant after a single UPSI episode if emergency contraception is not sought, compared with pregnancy rates of 1.1-2.6% in patients taking levonorgestrel within 72 hours.
Clomiphene is used to induce ovulation in patients with anovulatory infertility. It will not prevent implantation.
Danazol is a derivative of ethisterone. It can be used to treat endometriosis and fibrocystic breast disease. It will not prevent implantation and can cause virilisation of female fetuses, so is contraindicated in pregnancy.
The COCP prevents ovulation and is 99% effective at preventing pregnancy when taken correctly, but it will not prevent implantation if taken after an episode of UPSI.
A 22-year-old woman presents to her local sexual health clinic seeking emergency contraception after an episode of unprotected intercourse with a one-time male partner four days ago. She is on day 10 of her regular 30-day menstrual cycle, has no significant medical history, takes no medications, and reports no allergies. She expresses a preference for a non-invasive method of emergency contraception.
Following counselling about the need for sexually transmitted infection screening:
What is the most appropriate form of emergency contraception to prescribe?
Copper intrauterine device
Levonorgestrel
Levonorgestrel-releasing intrauterine system
No appropriate contraception is available
Ulipristal
Ulipristal
Ulipristal (EllaOne) - a type of emergency hormonal contraception, can be used up to 120 hours post UPSI
Ulipristal is the correct choice. This option, an oral hormonal emergency contraceptive, is minimally invasive and can be administered up to 120 hours following unprotected sexual intercourse. Therefore, the patient remains eligible for this form of contraception within the specified timeframe.
The copper intrauterine device is not the appropriate selection in this scenario. Despite being the most effective emergency contraceptive method and one that should always be considered, the patient’s preference for a non-invasive option must be respected. Given that ulipristal remains a viable alternative within her current window of opportunity, it represents a more suitable choice per her wishes.
Levonorgestrel does not represent a valid option here. Although levonorgestrel is another type of oral emergency hormonal contraceptive, its effectiveness extends only to within 72 hours (3 days) post-unprotected sexual intercourse; hence it would not serve this patient’s needs given the timing of her exposure.
The levonorgestrel-releasing intrauterine system (IUS) is also an incorrect choice. The IUS functions as a long-term hormonal contraceptive by thickening cervical mucus, impeding sperm mobility, and attenuating the endometrial lining to prevent fertilisation and implantation. However, due to inconclusive evidence regarding its use as an emergency contraceptive measure, it does not constitute an accepted practice for such purposes within the UK healthcare setting.
The option no appropriate contraception is available is incorrect. The patient engaged in unprotected sexual activity 4 days (96 hours) ago, which means she remains within the acceptable period for using both ulipristal and the copper intrauterine device as forms of emergency contraception. Ulipristal is likely to retain its efficacy at this stage since she is on day 10 of her typical 30-day menstrual cycle, indicating ovulation has probably not yet occurred; ovulation typically takes place around day 16.
A 22-year-old woman calls her GP surgery. The previous day she visited her pharmacist and was given the levonorgestrel emergency contraceptive pill following an episode of unprotected sexual intercourse. The patient explains to you that she wants a more reliable method of contraception.
You prescribe the combined oral contraceptive pill (COCP).
When can this patient start the COCP?
7 days after the emergency contraceptive pill
30 days after the emergency contraceptive pill
After she has had a negative pregnancy test
Immediately
The COCP is contraindicated
Immediately
Hormonal contraception can be started immediately after using levonorgestrel (Levonelle) for emergency contraception
Important for meLess important
After using the levonorgestrel emergency contraceptive pill, hormonal contraception can be started immediately.
Ulipristal may reduce the effectiveness of hormonal contraception. Contraception with the pill, patch, or ring should be started, or restarted, 5 days after having ulipristal. Barrier methods should be used during these 5 days.
7 days after the emergency contraceptive pill is incorrect. Levonorgestrel is not known to impact the efficacy of regular hormonal contraception. Therefore, there is no required time interval before restarting/starting hormonal contraception.
30 days after the emergency contraceptive pill is incorrect. Levonorgestrel is not known to impact the efficacy of regular hormonal contraception. Therefore, there is no required time interval before restarting/starting hormonal contraception.
After she has had a negative pregnancy test is incorrect. After taking levonorgestrel, a pregnancy test is not routinely recommended. According to NICE, a pregnancy test is only indicated if the patient’s next period is more than 5-7 days late or lighter than usual.
The COCP is contraindicated is incorrect. Using levonorgestrel is not a contraindication to the COCP. Contraindications of the COCP include current breast cancer, migraine with aura or, being aged over 35 years old and smoking more than 15 cigarettes per day.