PCOS_management_flashcards
What is Polycystic Ovarian Syndrome (PCOS)?
A complex condition of ovarian dysfunction affecting between 5-20% of women of reproductive age.
What percentage of women of reproductive age are thought to be affected by PCOS?
Between 5-20%.
What are two common physiological features seen in PCOS?
Hyperinsulinaemia and high levels of luteinizing hormone.
What general management strategy is recommended for PCOS if appropriate?
Weight reduction.
How can contraception help in managing PCOS?
A combined oral contraceptive (COC) pill may help regulate the cycle and induce a monthly bleed.
What management options are available for hirsutism and acne in PCOS?
COC pills, topical eflornithine, spironolactone, flutamide, and finasteride under specialist supervision.
Which combined oral contraceptive (COC) pills may help manage hirsutism?
A third generation COC with fewer androgenic effects or co-cyprindiol with anti-androgen action.
What are the risks associated with certain COC pills for managing hirsutism?
An increased risk of venous thromboembolism.
What topical treatment can be tried if hirsutism doesn’t respond to COC?
Topical eflornithine.
Which medications may be used for hirsutism under specialist supervision?
Spironolactone, flutamide, and finasteride.
What is the first step in managing infertility in PCOS if appropriate?
Weight reduction.
Who should supervise the management of infertility in PCOS patients?
A specialist.
What is the ongoing debate in the management of infertility in PCOS?
Whether metformin, clomifene, or a combination should be used to stimulate ovulation.
Which treatment was suggested as the most effective for infertility in a 2007 trial?
Clomifene.
What is the potential risk associated with clomifene?
A potential risk of multiple pregnancies.
