VIN_flashcards
What is Vulval Intraepithelial Neoplasia (VIN)?
VIN is a pre-cancerous skin lesion of the vulva that may result in squamous skin cancer if untreated.
What is the average age of a woman affected by VIN?
Around 50 years.
Name a primary viral risk factor for VIN.
Human papilloma virus (HPV) types 16 & 18.
Name two other risk factors for VIN.
Smoking and herpes simplex virus 2.
What skin condition is a risk factor for VIN?
Lichen sclerosus.
List two main symptoms of VIN.
Itching and burning.
Describe the appearance of VIN lesions.
Raised, well-defined skin lesions.
What is the primary method for diagnosing VIN?
Biopsy (punch biopsy or excisional biopsy).
What additional test is used for VIN and what does it detect?
HPV Testing using PCR or in situ hybridisation for high-risk HPV DNA.
Name two topical therapies used in the management of VIN.
Imiquimod and 5-Fluorouracil.
What is Imiquimod and its role in VIN management?
Imiquimod is an immune response modifier used as a topical therapy for VIN.
What is 5-Fluorouracil and its role in VIN management?
5-Fluorouracil is a topical chemotherapeutic agent used in VIN treatment.
What is the goal of surgical interventions for VIN?
Complete removal of dysplastic areas while preserving normal anatomy and function.
List three surgical techniques used for VIN.
Wide local excision, laser ablation, partial vulvectomy.
Why is follow-up and surveillance important in VIN management?
To monitor for recurrence or progression with repeat colposcopy and biopsy if needed.
