Hypothyroidism Flashcards

1
Q

What is the cause of congenital hypothyroidism?

A
  1. Agenesis or dysgenesis of the thyroid gland (75%)

2. Maternal thionamide use

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2
Q

How is congenital hypothyroidism diagnosed?

A
  1. Most at asymptomatic stage via newborn screening (detect TSH)
  2. Does not detect central congenital hypothyroidism (low/unpredictable TSH)
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3
Q

What is this a presentation of?
Good/quiet as they sleep for long periods, decreased activity, poor feeding, constipation, hypotonia, large posterior fontanelle, prolonged jaundice.

A

Congenital hypothyroidism

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4
Q

What is the management of hypothyroidism?

A

Lifelong thyroxine

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5
Q

What are the causes of acquired hypothyrodism?

A
  1. Hashimoto’s thyroiditis
  2. Prematurity
  3. Hypopituitarism
  4. Down’s syndrome
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6
Q

What is this a presentation of?

Slow growth, short stature, delayed puberty, declining school performance.

A

Acquired hypothyroidism

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7
Q

How is acquired hypothyroidism diagnosed?

A

Low T4/T3, high TSH.

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