4.3.1 Tumor markers Flashcards
Characteristics of an ideal tumor marker:
Should be Cancer-Sensitive and Tissue specific
T or F
T
Characteristics of an ideal tumor marker:
Shows elevation at the late stage of cancer
T or F
F
Early
Characteristics of an ideal tumor marker:
Serum levels correlate with tumor burden
T or F
T
Tumor markers can be use as stand alone test
T or F
F
Requires other test
Pancreatic
a. AFP
b. CEA
c. CA 15-3, 27.29
d. CA 19-1
d
Liver
a. AFP
b. CEA
c. CA 15-3, 27.29
d. CA 19-1
a
Colorectal
a. AFP
b. CEA
c. CA 15-3, 27.29
d. CA 19-1
b
Breast
a. AFP
b. CEA
c. CA 15-3, 27.29
d. CA 19-1
c
Increase in germ cell tumors
a. AFP
b. CEA
c. CA 15-3, 27.29
d. CA 19-1
a
Related to lewis Blood group antigens
a. AFP
b. CEA
c. CA 15-3, 27.29
d. CA 19-1
d
Increase in gastric and colorectal cancer
a. AFP
b. CEA
c. CA 15-3, 27.29
d. CA 19-1
d
Same with CA 72-4 and CEA
Breast
a. CA 72-4
b. CA 125
c. CYFRA 21-2
d. ER, PR, HER-2/neu
d
Ovarian
a. CA 72-4
b. CA 125
c. CYFRA 21-2
d. ER, PR, HER-2/neu
b
Gastric
a. CA 72-4
b. CA 125
c. CYFRA 21-2
d. ER, PR, HER-2/neu
a
Lung
a. CA 72-4
b. CA 125
c. CYFRA 21-2
d. ER, PR, HER-2/neu
c
Increase in colorectal cancer
a. CA 72-4
b. CA 125
c. CYFRA 21-2
d. ER, PR, HER-2/neu
a
Increase with Gynecological conditions
a. CA 72-4
b. CA 125
c. CYFRA 21-2
d. ER, PR, HER-2/neu
b
Subunit of Cytokeratin fragment
a. CA 72-4
b. CA 125
c. CYFRA 21-2
d. ER, PR, HER-2/neu
c
Urinary bladder
a. PSA
b. NMP
c. Beta hCG
d. Thyroglobulin
b
Prostatic
a. PSA
b. NMP
c. Beta hCG
d. Thyroglobulin
a
Thyroid
a. PSA
b. NMP
c. Beta hCG
d. Thyroglobulin
d
Ovarian / Testicular
a. PSA
b. NMP
c. Beta hCG
d. Thyroglobulin
c
Used for screening in combination with DRE
a. PSA
b. NMP
c. Beta hCG
d. Thyroglobulin
a
Oncogene-encoded protein
a. PSA
b. NMP
c. Beta hCG
d. Thyroglobulin
b
Neuroblastoma
a. HVA, VMA
b. MN, nMN
a
Phaeochromocytoma
a. HVA, VMA
b. MN, nMN
b
24-h urine; HPLC
a. HVA, VMA
b. MN, nMN
a
24-h urine OR plasma ; HPLC
a. HVA, VMA
b. MN, nMN
b
For catecholamines
a. Immunoassay
b. HPLC
c. Enzyme assays
d. Immunohistochemistry
b
For receptor markers
a. Immunoassay
b. HPLC
c. Enzyme assays
d. Immunohistochemistry
d
Gestational Thromboplastic disease/aplasia
a. Immunoassay
b. HPLC
c. Enzyme assays
d. Immunohistochemistry
d
Tumor markers:
CEA can correlate with CA 72-4 since it can detect colorectal
T or F
T
CA 125 and beta hCG is almost the same because the tumor type is ovarian
T or F
T
CA 125: Ovarian
beta hCG: Ovarian/Testicular
