2.4.3 Proteins (Serum protein Fractions) Flashcards
Indicator of malnutrition
a. Pre albumin
b. Albumin
a
Major contributor to plasma oncotic/osmotic pressure
a. Pre albumin
b. Albumin
b
Binds/Transport T4 as Transthyretin/TBPA
a. Pre albumin
b. Albumin
a
Forms a complex with retinol Binding protein (RBP)
a. Pre albumin
b. Albumin
a
Second most abundant protein fraction in CSF
a. Pre albumin
b. Albumin
a
General transport protein
a. Pre albumin
b. Albumin
b
Decrease levels in Nephrotic syndrome, protein-losing enteropathy and liver disease
a. Pre albumin
b. Albumin
c. Haptoglobulin
d. Transferrin
b
Most abundant fraction
a. Pre albumin
b. Albumin
b
This is not distinct in Serum electrophoresis
a. Pre albumin
b. Albumin
c. Immunoglobulin
d. CRP
a
Absence of albumin
a. Analbuminemia
b. bisalbuminemia
a
Albumin
Negative APR: Decrease in_______________
a. Transport of substance
b. Inflammation
c. Analytes
d. None of the above
b
The following are Alpha 1 protein except:
- πΆ-Fetroprotein
- πΆ1- Antitrypsin
- πΆ1- Acid glycoprotein
- πΆ1-Antichymotrypsin
- Gc-globulin
- Haptoglobulin
Haptoglobulin ( πΆ2)
Increase levels in amniotic fluid NEURAL TUBE DEFECT
a. πΆ-Fetroprotein
b. πΆ1- Antitrypsin
c. πΆ1- Acid glycoprotein
d. πΆ1-Antichymotrypsin
e. Gc-globulin
a
Acute Phase Reactant
a. πΆ-Fetroprotein
b. πΆ1- Antitrypsin
c. πΆ1- Acid glycoprotein
d. πΆ1-Antichymotrypsin
e. Gc-globulin
b and c
Transport Vit D
a. πΆ-Fetroprotein
b. πΆ1- Antitrypsin
c. πΆ1- Acid glycoprotein
d. πΆ1-Antichymotrypsin
e. Gc-globulin
e
Protease inhibitor
a. πΆ-Fetroprotein
b. πΆ1- Antitrypsin
c. πΆ1- Acid glycoprotein
d. πΆ1-Antichymotrypsin
e. Gc-globulin
b and d
Binds progesterone and some drugs
a. πΆ-Fetroprotein
b. πΆ1- Antitrypsin
c. πΆ1- Acid glycoprotein
d. πΆ1-Antichymotrypsin
e. Gc-globulin
c
Major component for alpha 1 region?
a. πΆ-Fetroprotein
b. πΆ1- Antitrypsin
c. πΆ1- Acid glycoprotein
d. πΆ1-Antichymotrypsin
e. Gc-globulin
b
Increase level in adult serum which may cause Hepatocellular CA/Liver cancer
a. πΆ-Fetroprotein
b. πΆ1- Antitrypsin
c. πΆ1- Acid glycoprotein
d. πΆ1-Antichymotrypsin
e. Gc-globulin
a
Deficiency is associated with SERPINA 1 gene mutation and causes juvenile hepatic cirrhosis and pulmonary emphysema
a. πΆ-Fetroprotein
b. πΆ1- Antitrypsin
c. πΆ1- Acid glycoprotein
d. πΆ1-Antichymotrypsin
e. Gc-globulin
b
Binds prostate specific antigen
a. πΆ-Fetroprotein
b. πΆ1- Antitrypsin
c. πΆ1- Acid glycoprotein
d. πΆ1-Antichymotrypsin
e. Gc-globulin
d
Decrease level may lead to abnormal calcium level
a. πΆ-Fetroprotein
b. πΆ1- Antitrypsin
c. πΆ1- Acid glycoprotein
d. πΆ1-Antichymotrypsin
e. Gc-globulin
e
Negatively charged even in in pH, has a very high CHO content
a. πΆ-Fetroprotein
b. πΆ1- Antitrypsin
c. πΆ1- Acid glycoprotein
d. πΆ1-Antichymotrypsin
e. Gc-globulin
c
The following are Alpha 2 protein except:
- πΆ2-Macroglobulin
- Hepatoglobulin
- Ceruplasmin
- Transferrin
- Hemopexin
Transferrin and Hemopexin
A Protease inhibitor and the largest non-Ig protein
a. πΆ2-Macroglobulin
b. Hepatoglobulin
c. Ceruloplasmin
a
The following are PROTEASE INHIBITOR except:
- πΆ2-Macroglobulin
- πΆ1-Antitrypsin
- πΆ1- antichymotrypisin
- πΆ1- Acid glycoprotein
- πΆ1- Acid glycoprotein
An acute Phase reactant that BINDS to hemoglobin to PRESERVE IRON
a. πΆ2-Macroglobulin
b. Hepatoglobulin
c. Ceruloplasmin
b
An acute phase reactant that is a binding protein and has oxidase activity
a. πΆ2-Macroglobulin
b. Hepatoglobulin
c. Ceruloplasmin
c
Increase ten-fold in Nephrotic syndrome and protein-losing enteropathy
a. πΆ2-Macroglobulin
b. Hepatoglobulin
c. Ceruloplasmin
a
same with albumin but decrease
Decrease level seen in hemolytic disorders/Intravascular hemolysis
a. πΆ2-Macroglobulin
b. Hepatoglobulin
c. Ceruloplasmin
b
Decrease level seen in Wilsonβs disease
a. πΆ2-Macroglobulin
b. Hepatoglobulin
c. Ceruloplasmin
c
The following are acute phase reactant except:
- Haptoglobulin
- Ceruloplasmin
- πΆπ- Antitrypsin
- πΆπ - Acid glycoprotein
None
Serve as both APR and protease inhibitor
a. Haptoglobulin
b. Ceruloplasmin
c. πΆπ- Antitrypsin
d. πΆπ - Acid glycoprotein
c
The following are beta globulins except:
- Transferrin
- C3 complement
- Hemopexiin
- Ξ2-microglobulin
- CRP
CRP
Immune response
a. Transferrin
b. C3 complement
c. Hemopexiin
d. Ξ2-microglobulin
b
Transports iron
a. Transferrin
b. C3 complement
c. Hemopexiin
d. Ξ2-microglobulin
a
What is the difference between transferrin and haptoglobin?
Haptoglobulin: Preserves iron
Transferrin: Transport iron
Binds heme
a. Transferrin
b. C3 complement
c. Hemopexiin
d. Ξ2-microglobulin
c
Component of MHC or HLA molecules
a. Transferrin
b. C3 complement
c. Hemopexiin
d. Ξ2-microglobulin
d
Increase level seen in Iron deficiency anemia
a. Transferrin
b. C3 complement
c. Hemopexiin
d. Ξ2-microglobulin
a
Mos abundant complement component?
C3 complement
Decrease level in intavascular hemolysis
a. Transferrin
b. C3 complement
c. Hemopexiin
d. Ξ2-microglobulin
c
Use to measure GFR
a. Transferrin
b. C3 complement
c. Hemopexiin
d. Ξ2-microglobulin
d
The followin are gamma protein except:
- C-reactive protein
- IgG
- IgM
- Immunoglobulins
None
Increased up to 1000 times i inflammatory states; hs CRP used as marker for cardiovascular disorder
a. C-reactive protein
b. Immunoglobulins
a
Immunoglobulins are produced by what cell?
Plasma cell/Memory cell/B cell
Extra bands is seen if specimen is:
Plasma = __________
- Forms a band between beta and _______ region
Hemolyzed = Hemoglobin
- Forms a band between alpha 2 and beta
Fibrinogen
- gamma region
