2.2.5 Lipids and Lipoproteins (Hypolipoproteinemias)

Question 1

The main cause of Hypolipoproteinemia?

a. Genetic mutation
b. Lack of consumption of Lipoproteins
c. All of the above
d. None of the above

Answer 1

a

Question 2

Also known as Bassen-Kornzweig syndrome

a. Abetalipoproteinemia
b. Hypobetalipoproteinemia
c. Tangler disease
d. Hypoalpholipoprteinemia

Answer 2

a

Question 3

An autosomal dominant disorder caused by nonsense or missense mutations in the apoB gene

Low TC, normal to low TG

a. Abetalipoproteinemia
b. Hypobetalipoproteinemia
c. Tangler disease
d. Hypoalpholipoprteinemia

Answer 3

b

Question 4

An autosomal recessive disorder involving mutations in the MTTP gene with absolute nonexistent levels of apoB48 and apoB100

a. Abetalipoproteinemia
b. Hypobetalipoproteinemia
c. Tangler disease
d. Hypoalpholipoprteinemia

Answer 4

a

Question 5

Absence of apoB lipoproteins (VLDL, IDL, LDL, CM)

TC = Very low
Triglyceride = nearly undetectable

a. Abetalipoproteinemia
b. Hypobetalipoproteinemia
c. Tangler disease
d. Hypoalpholipoprteinemia

Answer 5

a

Question 6

Autosomal recessive disorder characterized by low to undetectable HDL due to a mutation in ABCA1 gene

a. Abetalipoproteinemia
b. Hypobetalipoproteinemia
c. Tangler disease
d. Hypoalpholipoprteinemia

Answer 6

c

Question 7

Defect in HDL

a. Abetalipoproteinemia
b. Hypobetalipoproteinemia
c. Tangler disease
d. Hypoalpholipoprteinemia

Answer 7

c and d

Question 8

Common autosomal dominant disorder characterized by HDL-C levels

a. Abetalipoproteinemia
b. Hypobetalipoproteinemia
c. Tangler disease
d. Hypoalpholipoprteinemia

Answer 8

d

Question 9

Low levels of HDL:

Men: <30 mg/dl
Woman: <40 mg/dl

T or F

Answer 9

T