2.3.3 Nonprotein Nitrogen Compounds (Uric Acid)

Question 1

Uric acid constitutes _______ of plasma NPNs

Answer 1

10-20%

Question 2

Uric acid is a product of purine catabolism of purines in nucleic acids or nucleoproteins

T or F

Answer 2

T

Question 3

Uric acid is soluble in plasma

T or F

Answer 3

F

Insoluble

Question 4

Can be deposited in the joints and tissues at concentration > _______ causing inflammation

a. 6.8 mg/dL
b. 6.9 mg/dL
c. 6.7 mg/dL
d. 6.6 mg/dL

Answer 4

a

Question 5

Chemical Method for Uric acid?

a. Jaffe method
b. Phophotungstic Acid method
c. Fearon Method

Answer 5

b

Question 6

Phosphotungstic Acid Method is colorimetric

T or F

Answer 6

T

Question 7

All test chemical methods used in NPN are Colorimetric

T or F

Answer 7

T

Question 8

Color of Tungsten in Phosphotungstic Acid Method

Answer 8

Blue

Question 9

What is the final product in Phosphotungstic method?

a. Sarcosine
b. Oxidized chromogen
c. Allantoin
d. Tungsten
e. CO2

Answer 9

c, d, e

Question 10

Enzymatic method for Uric acid:

What is the enzyme used?

a. Uricase
b. Urease

Answer 10

a

Question 11

Enzymatic method for Uric acid:

It involves the hydrolysis of uric acid to allantoin, carbon dioxide and
hydrogen peroxide

T or F

Answer 11

T

Question 12

Absorbance of Allantoin?

a. 293 nm
b. 340 nm
c. 537 nm

Answer 12

a

Question 13

Reference interval for uric acid:

Male: 3.5 - _______ mg/dL
Female: _____ - 6.0 mg/dL

Answer 13

7.2

2.6

Question 14

Clinical Significance of Abnormal Values for uric acid:

Gout, leukemia, chemotherapy, chronic nephritis, Leschnyhan syndrome

a. Hyperuricemia
b. Hypouricemia

Answer 14

a

Question 15

In hyperuricemia;

Gout, leukemia, chemotherapy

a. Increased production
b. decreased excretion

Answer 15

a

Question 16

In hyperuricemia;

Chronic nephritis/renal failure, alcoholism, Leschnyhan syndrome

a. Increased production
b. decreased excretion

Answer 16

b

Question 17

An inborne error of metabolism resulting from a deficiency of hypoxanthine-guanine phosphoribosyltransferase

a. Lesch-Nyhan syndrome
b. Orange sand diaper syndrome
c. All of the above

Answer 17

c

Both same, just different term

Question 18

Clinical Significance of Abnormal Values for uric acid:

Fanconi syndrome, severe liver disease, purine inhibitors,
allopurino

a. Hyperuricemia
b. Hypouricemia

Answer 18

b

Question 19

In hypouricemia;

Purine inhibitors, allopurinol

a. decreased production
b. decreased tubular reabsorption

Answer 19

a

Question 20

In hypouricemia;

Fanconi syndrome

a. decreased production
b. decreased tubular reabsorption

Answer 20

d