3.2.1.1 Clinical Enzymology (Creatine Kinase)

Question 1

Tissue sources includes:
- Brain
- Mycocardium
- Skeletal muscle

a. Creatinine kinase
b. Lactate dehydrogenase
c. Aminotransferase
d. Alkaline phosphatase
e. Amylase
f. Lipase

Answer 1

a

Question 2

Creatinine:

Pronounced elevation and mild to moderate elevation can be detected in CSF IF there is brain damage

T or F

Answer 2

T

Question 3

Creatinine:

Pronounced elevation and mild to moderate elevation can be detected in Serum IF there is damage related to Muscle and mycocardium

T or F

Answer 3

T

Question 4

Creatinine

The degree of elevation for this is more than or equal to 5 times

a. Pronounced elevation
b. Mild to moderate Elevation

Answer 4

a

Question 5

Creatinine

The degree of elevation for this is more than or equal to 2-4 times

a. Pronounced elevation
b. Mild to moderate Elevation

Answer 5

b

Question 6

In pronounced elevation:

Duchenne’s muscular dystrophy has the highest __ elevation

a. AST
b. CK
c. ALP
d. AKP

Answer 6

b

Question 7

Polymyositis, dermatomyositis, myocardial infarction, DMD can be seen usually in

a. Pronounced elevation
b. Mild to moderate Elevation

Answer 7

a

Question 8

Acute agitated psychosis
Alcoholic myopathy
Severe exercise

These can be seen in:

a. Pronounced elevation
b. Mild to moderate Elevation

Answer 8

b

Question 9

Fastest isoenzymes

a. CK-BB (CK1)
b. CK-MB (CK2)
c. CK-MM (CK3)

Answer 9

a

Question 10

Slowest Isoenzymes

a. CK-BB (CK1)
b. CK-MB (CK2)
c. CK-MM (CK3)

Answer 10

c

Question 11

The direction of Isoenzymes is from Cathode (-) to Anode (+)

T or F

Answer 11

T

Question 12

Isoenzymes from Slowest to Fastest

_____, ____, Macro, ___, _____

Answer 12

MI, MM, Macro, MB, BB

Question 13

Isoenzymes:

MI (CK-MI) means?

Answer 13

Mitochondrial

Question 14

Between MM and MB

a. CK-MI
b. Macro-CK

Answer 14

b

Question 15

Cathodal to MM

a. CK-MI
b. Macro-CK

Answer 15

a

Question 16

________ is released indicating extensive tissue damage which means necrosis

a. CK-BB (CK1)
b. CK-MB (CK2)
c. CK-MM (CK3)
d. None of the above

Answer 16

d

CK-MI

Question 17

Most abundant/Major isoenzyme found in striated muscle and normal serum (94-100%)

a. CK-BB (CK1)
b. CK-MB (CK2)
c. CK-MM (CK3)
d. None of the above

Answer 17

c

Question 18

Present in significant amounts in the CARDIAC tissue; Normal value is <6% of Total CK in serum

a. CK-BB (CK1)
b. CK-MB (CK2)
c. CK-MM (CK3)
d. None of the above

Answer 18

b

Question 19

If CK-MB (CK2) is over 6%, this indicates?

Answer 19

Myocardial infarction

Question 20

Elevated in CNS damage, tumors, presence of macro-CK

a. CK-BB (CK1)
b. CK-MB (CK2)
c. CK-MM (CK3)
d. None of the above

Answer 20

a

Question 21

Macro CK is also known as?

Answer 21

CK-BB that is attach to Type 1 Macroenzyme (Immunoglobulin)