3.2.4.1 Clinical Enzymology (Alkaline Phosphatase) Flashcards
Tissue sources includes:
- Liver
- Bone
- Placenta
- Intestine
a. Creatinine kinase
b. Lactate dehydrogenase
c. Aminotransferase
d. Alkaline phosphatase
e. Amylase
f. Lipase
d
Pronounced Elevation of ALP is mostly on what organ?
Liver and bone
Hepative biliary Disorders (Bile duct obstruction, biliary cirrhosis), Paget’s disease, Osteogenic sarcoma, hyperparathyroidism
a. Pronounced
b. Moderate
c. Slight
a
The source of Highest ALP elevation?
a. HBO
b. Paget’s Disease
c. hyperparathyroidism
d. Osteosarcoma
b
Rickets and osteomalacia
a. Pronounced
b. Moderate
c. Slight
b
Rickets and osteomalacia are the consequence of Vitamin ___ deficiency
D
Healing bone fractures, growing children
a. Pronounced
b. Moderate
c. Slight
c
Pregnancy (Placenta)
a. Pronounced
b. Moderate
c. Slight
c
Placenta ALP ONLY Contributes during Pregnancy
T or F
T
Isoenzyme analysis base on Electrophoresis:
Arrange from Cathodal to Anodal
a. Liver
b. Bone
c. Placenta
d. Intestine
a,b,c,d
Isoenzyme analysis base on Heat stability:
Arrange from Most heat stable to the least
a. Liver
b. Bone
c. Placenta
d. Intestine
c,d,a,b
In Heat stability:
Bone ALP, <20% activity at _______
a. 65C
b. 56C
c. 50C
d. 70C
b
In Heat stability:
Placental ALP Resist heating at _______ for _______
a. 65C, 30 mins
b. 56C, 30 mins
c. 65C, 30 sec
d. 56C, 30 sec
a
Isoenzyme analysis base on Chemical inhibition:
Urea is most notable since it inhibits one isoenzyme which is?
a. Liver
b. Bone
c. Placenta
d. Intestine
e. Carcinoplacental
b
Isoenzyme analysis base on Chemical inhibition:
Levamisole inhibits?
a. Liver
b. Bone
c. Placenta
d. Intestine
e. Carcinoplacental
a and b
Isoenzyme analysis base on Chemical inhibition:
Phenylalanine inhibits?
a. Liver
b. Bone
c. Placenta
d. Intestine
e. Carcinoplacental
c, e and d
Isoenzyme analysis base on Chemical inhibition:
Associated with B or O secretors which are increased after consumption of a fatty meal
a. Liver
b. Bone
c. Placenta
d. Intestine
e. Carcinoplacental
d
Intestinal ALP
Carcinoplacental is a nonspecific tumor marker that abnormally produces isoenzymes
T or F
T
Most heat stable than normal Isoenzymes
a. Regan
b. Nagao
c. Kasahara
a
Inhibited by phenylalanine
a. Regan
b. Nagao
c. Kasahara
All
Variant of Regan
a. Regan
b. Nagao
c. Kasahara
b
Inhibited by leucine
a. Regan
b. Nagao
c. Kasahara
b
Associated with hepatic and GI tumors
a. Regan
b. Nagao
c. Kasahara
c
