3.2.2.1 Clinical Enzymology (Lactate Dehydrogenase) Flashcards
Lactate dehydrogenase (LDH) is the most ubiquitous since it can be produce by several tissues
T or F
T
Since LDH is ubiquitous, it is the least specific since you don’t know where it can be produce
T or F
T
LDH is a tetra peptide meaning, it consist of ____ peptide unit
4
ex:
H4
H3M1
Major tissue source:
Lungs, lymphocytes, spleen, pancreas
a. LD1
b. LD2
c. LD3
d. LD4
e. LD5
c
Major tissue source:
Liver, skeletal muscles
a. LD1
b. LD2
c. LD3
d. LD4
e. LD5
d and e
Major tissue source:
Heart, RBCs, renal cortex
a. LD1
b. LD2
c. LD3
d. LD4
e. LD5
a and b
H4
a. LD1
b. LD2
c. LD3
d. LD4
e. LD5
a
H3M1
a. LD1
b. LD2
c. LD3
d. LD4
e. LD5
b
H2M2
a. LD1
b. LD2
c. LD3
d. LD4
e. LD5
c
M4
a. LD1
b. LD2
c. LD3
d. LD4
e. LD5
e
H1M3
a. LD1
b. LD2
c. LD3
d. LD4
e. LD5
d
Most anodal (Fastest)
a. LD1
b. LD2
c. LD3
d. LD4
e. LD5
a
Most Cathodal (Slowest)
a. LD1
b. LD2
c. LD3
d. LD4
e. LD5
e
LD2 is abundant than LD1
T or F
F
LD1 is mostly abundant than LD2
Normal serum ratio:
LD2 > LD1
T or F
T
Flipped ration in SERUM:
LD1 > LD2
T or F
T
Does flipped Serum ratio indicate damage such as hemolytic anemia, MI, and Renal inflammation?
T or F
LD1 is inside that particular organ and due to injury, it release into the serum which is the reason why LD1 is greater than LD2
Associated with:
arteriosclerotic, cardiovascular failure, CATHODIC to LD5 (Slower the LD5) signifying grave prognosis and impending death
LD6
> 5 x
a. Pronounced elevation
b. Moderate elevation
c. Slight elecation
a
> 3 x
a. Pronounced elevation
b. Moderate elevation
c. Slight elecation
b
Up to 3 x
a. Pronounced elevation
b. Moderate elevation
c. Slight elecation
c
Highest LD elevation (Pronounced elevation)
a. Hemolysis
b. Renal infarction
c. Systemic shock
d. Megaloblastic anemia
d
What is the hematologic defect of megaloblastic anemia due to a deficiency in Vit B12?
a. Cytoplasm matures first then nucleus (asynchronous)
b. Impair synthesis
c. Ineffective erythropoiesis
d. All of the above
c
Production of RBC is not released properly due to RBCs being destroyed in the bone marrow
RULE of the Bone Marrow:
if you are abnormal, you are not release
Myocardial Infarction, Hemolytic conditions, pulmonary infarction, muscular dystrophy, delirium tremens, leukemias, IM
a. Pronounced elevation
b. Moderate elevation
c. Slight elevation
b
Most liver diseases, nephrotic syndrome, hypothyroidism, cholangitis
a. Pronounced elevation
b. Moderate elevation
c. Slight elecation
c
