Signal Transduction Flashcards
Topics

Fundamentals of Molecular Medicine

What is Cancer?

Percent Distribution of Cancer

Cancer Death Rates

Cancer Rates/Trends

Cancer Treatment Types

Distribution of Cancer Sites

Erythropoetin and JAK-STAT Transduction




Erythroid Hyperplasia in Bone Marrow





Normal Cells and Signaling Events

Serum and Cells that are starved from Serum

Cyclohexamide

Immediate Early Proteins and Delayed Early Genes

James Bond Model of Cancer

Oncogenes

Selected Oncogenes and Their Mode of Activation

Oncogenes and RAS

RAS and Cancer

Receptor that Activates RAS

Paracrine Growth Factors

Autocrine Growth Factors

Antibodies and Cancer Therapies

Herceptin

Blood Brain Barrier and Cancer

Steroid Hormones

RAS activation favors…

MYC and Cyclin D

Cyclin D

Retinoblastoma and Cancer
Which Cell Cycle is Effected?

Constitutive Activation

Mode of Activation of Selected Oncogenes

Result of Constitutive Activation

Constitutively Activated Receptors in Cancer

RAS and Point Mutations

RAS Point Mutations And Downstream Kinases

Effects of RAS Activation/Point Mutation

mTOR

Function of mTOR

Rapamycin Derative and Tumors

Complexity of mTOR Interactions

ABL

ABL Translocation

BCR ABL and Gleevec

Polycythemia

Jakafi

Proteosome

Cachexia and Inhibitors of Proteosomes

Velcade

Two Ways to Reduce Cell Cancer Growth

Getting Cancer Treatments into The Body
