Signal Transduction Flashcards

1
Q

Topics

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2
Q

Fundamentals of Molecular Medicine

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3
Q

What is Cancer?

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4
Q

Percent Distribution of Cancer

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5
Q

Cancer Death Rates

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6
Q

Cancer Rates/Trends

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7
Q

Cancer Treatment Types

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8
Q

Distribution of Cancer Sites

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9
Q

Erythropoetin and JAK-STAT Transduction

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10
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11
Q
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Erythroid Hyperplasia in Bone Marrow

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12
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13
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14
Q

Normal Cells and Signaling Events

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15
Q

Serum and Cells that are starved from Serum

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16
Q

Cyclohexamide

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17
Q

Immediate Early Proteins and Delayed Early Genes

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18
Q

James Bond Model of Cancer

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19
Q

Oncogenes

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20
Q

Selected Oncogenes and Their Mode of Activation

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21
Q

Oncogenes and RAS

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22
Q

RAS and Cancer

23
Q

Receptor that Activates RAS

24
Q

Paracrine Growth Factors

25
Q

Autocrine Growth Factors

26
Q

Antibodies and Cancer Therapies

27
Q

Herceptin

28
Q

Blood Brain Barrier and Cancer

29
Q

Steroid Hormones

30
Q

RAS activation favors…

31
Q

MYC and Cyclin D

32
Q

Cyclin D

33
Q

Retinoblastoma and Cancer

Which Cell Cycle is Effected?

34
Q

Constitutive Activation

35
Q

Mode of Activation of Selected Oncogenes

36
Q

Result of Constitutive Activation

37
Q

Constitutively Activated Receptors in Cancer

38
Q

RAS and Point Mutations

39
Q

RAS Point Mutations And Downstream Kinases

40
Q

Effects of RAS Activation/Point Mutation

42
Q

Function of mTOR

43
Q

Rapamycin Derative and Tumors

44
Q

Complexity of mTOR Interactions

46
Q

ABL Translocation

47
Q

BCR ABL and Gleevec

48
Q

Polycythemia

49
Q

Jakafi

50
Q

Proteosome

51
Q

Cachexia and Inhibitors of Proteosomes

52
Q

Velcade

53
Q

Two Ways to Reduce Cell Cancer Growth

54
Q

Getting Cancer Treatments into The Body