Cancer Genetics Flashcards by Omar Saqr

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Topics

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What is Cancer?

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Cancer Treatment Types

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Cancer Screening

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Constitutional Cancer Symptoms

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Other Symptoms

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Complex Traits

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Sporadic Mutations

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Familial Mutations

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Hereditary

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Frequency of Sporadic vs. Familial vs. Hereditary

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Indications of Family Cancer Syndromes

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Tumor Supressor Genes and Loss of Heterozygosity

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James Bond Model for Cancer

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Knudson Hypothesis

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LiFraumani Syndrome and the Function of P53

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Cause of Retinoblastoma and function of RB1

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CDK, RB, and E2F Interplay

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Cause of Hereditary Breast Cancer

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Function of BRCA1 and 2

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PARP-1 Inhibitors

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Cause of Familial Adenomatous Polyposis

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Interplay of Beta Catenin and APC

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Mutations Downstream from APC

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Cause of Wilms Tumor and WT1

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Cause of Neurofibromatosis Type 1 and role of underlying gene

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What is the most Common Form of Skin Cancer in the US

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Most Common Form of Skin Cancer

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Role of Patched

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Role of SMO

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Interplay of PTCH and SMO in Normal Cells

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Stimilation of Proliferation in Normal Cells

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What happens when PTCH Mutates?

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Familial Mutation of PTCH

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Targeted Therapy

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Cause of Familial Melanoma and it’s underlying Gene

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Role of P14

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Malignant Melanoma and Squamous Cell Carcinoma

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