Fatty Acids Flashcards
Figure this out by the end of the lecture
Overview of Fatty Acid Metabolism
Why is fatty acid storage more compact and a better energy storage than glycogen?
Smaller molecule
Larger molecule
Hydrophobic Effect
Ionic effect
Hydrophobic Effect
What are Fatty Acids?
Palmitate
Palmitolate
Stearate
Oleate
Linoleate
Linolenate
Arachadonic Acid
Biological Functions of Fatty Acids
Triacylglycerol
Membrane Structures
Release of FA from Adipose and the Enzymes involved.
Triglyceride Degredation
When fatty acids are released from the fat cell they are carried by serum albumin?
They are specific receptors for serum albumin on tissues, but not for fatty acids
The fatty acids would precipitate in serum unless bound to albumin
The fatty acids would bind to membrane components and not travel to target tissues
the fatty acids can only enter the nerves system if bound to albumin
The fatty acids would precipitate in serum unless bound to albumin
How long must a chain be to be soluble?
Once you get larger than 8 carbon fatty acids it starts to precipitate
What Carries FA in the Blood? and Why?
Albumin is the most abundant protein in your blood stream.
What other protein is activated by PKA
Liver phosphorylase (activated by phosphorylase kinase)
Muscle Phosphorylase
Protein phosphatase 1
Protein Inhibitor 1
glycogen synthase (Inhibited by PKA)
Protein Inhibitor 1
What Happens to the Glycerol Produced?
G3PDH is also needed for what pathway?
Glycolysis
Glucogneogeneiss
An electron shunt pathway
Glycogen Degredation
Glycogen synthesis
An electron shunt pathway
How many high-energy phosphate bonds are required to convert two molecules of glycerol to one molecule of glucose in the liver?
0
1
2
3
4
5
6
2
Lactate requires 6 Atps to get to Glucose but glycerol only needs 2. But there’s much more Lactate than Glycerol.
What Happens to the Fatty Acids?
Feeding Experiments
Beta Oxidation
Similarities to TCA Cycle
Fatty Acid Oxidation Reactions
Big Picture of Fatty Acid Oxidation
Fatty Acid Oxidation
Overview of Fatty Acid Oxidation
Fatty Acid Transport into the Mitochondria
Acetyl CoA vs. Acyl CoA
Acetyl CoA — this specifies that the CoA is directly linked to the Acetyl group.
Acyl CoA— Hydrocarbon chain linked to CoA
What would you expect to happen in fan individual had a CPT II deficiency?
Fasting Hyperglycemia
Fasting Hypoglycemia
Reduced glycolytic rate
No effect on metabolism
Fasting Hypoglycemia — Liver will have trouble maintaining blood glucose levels.