Drug Absorption Flashcards by Omar Saqr | Brainscape

Q

ADME

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Routes by Which Solutes can Transverse Membrane

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Drug Absorption and Distribution

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Q

Drug Characterisitics that Favor Diffusion

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Q

Acid

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Base

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Q

Weak Acid/Base

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Q

Weak Acid/Base

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Q

Common Drug Acid/Base Functional Groups

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Acids/Bases Vs. Pka’s

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Examples of Weak Acids and Bases

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Weak Acid and Permeability

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Weak Base and Permeability

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Q

Henderson Hasselbach Equation

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Q

What are the most important determinants of moving accross the membrane?

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Q

Importance of Hydrophobicity for Drugs with Similar Pka Values

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Q

Transcapillary Movement

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Q

Blood Brain Barrier

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Q

Routes for Drug Administration and Elimination

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Q

IV vs. First Pass Effect

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Why is first pass effect a challenge Clinically?

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Oral Administration Advantages vs. Disadvantages and First pass Metabolism

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Stomach, Small Intestine, Large Intestine

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Sub-Buccal/Sub Lingual Absorption and Absorption Rates

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Paraternal Administration (Lungs)

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Paraternal Administration (Skin)

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Intramuscular vs. Subcutaneous

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Intravenous

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Epidural

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Intrathecal

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Intraperitoneal

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Routes vs. Time Administration with Cocaine

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Thiopental a lipid soluble anasthetic

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Major Determinants of Drug Absorption from the Gut

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Q

Placental Fetus/Milk/Uncharged Drugs

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Q

Volume of Distribution

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Plasma Volume for Different Drugs

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Low vs. High Vd

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Drugs that Bind to Albumin

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Bioavailability

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Drug Metabolism

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Two Phases of Drug Metabolism

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Drugs and Phases

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Overdose Toxicity and Acetominophen

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Liver Cytochrome P450

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Drugs and Age Considerations

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Pharmacogenetics

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pH and Resorbtion

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