CILS: Accumulations and Adaptations Flashcards
T or F. Inclusion bodies due to viral infections can occur within the cytoplasmic space and can occur within nuclei?
True — Viruses need replication machinery present in the nucleus — Lead to Negri Bodies
Herpes Virus builds up in both locations as well.
CMV — Cytomegalovirus— “Big Cell” — Owl’s Eye — or Cowdry Type A inclusions. — nuclear inclusions and granular
Cellular Atypia is not a histopathologic feature of Dysplasia? T or F?
False
All accumulations are the result of either a cell’s rate of production exceeding clearance or else the failure to metabolize an endogenous substance.
False — Coal Dust, Pollution, Melanoma
Dysplasia is often a precursor to malignant transformation. T or F?
True
With amyloidosis the heart liver or kindness are not common sites.
False
A feature shared in common by both accumulations and adaptations is that both can arise from physiological and pathologic stimuli.
True
Both
Cytomegalovirus
Hypertrophy — “Box car Changes”
Systolic
Features of Dystrophic Calcification
Atrioventricular closing shut — lub
Aortic Valve and Pulmonary Artery Close — Dub
Lub Shuh Dub — Systolic Murmur — blood is having a hard time getting out of the ventricular chamber and into the aorta.
If you have dystrophic calcification it will have a hard time getting out of the aorta.
Hyperplasia.
Lymphocyte hyperplasia which are reacting to some sort of infection.
Prussian blue stains — stains iron.
Build up of iron in liver.
High Ferritin associated with high total body Iron levels.
Longer Prothrombin time means blood is taking longer to clot than normal.
Liver makes clotting Factors
Primary Hemochromatosis. (Answer) Inherited form — autosomal recessive — Genetic Form
Secondary Hemochromatosis — Multiple Transfusions — Iron buildup (sometimes called Hemosiderosis)
Hemosiderosis — There’s no anemia. Sometimes only refers Iron buildup as a result of macrophage activity.
Excessive absorption of iron from the gastrointestinal tract.
Cardiac Biopsy from a middle aged man.
Hypo-chromatic. Less organization.
Deposits of Amyloids.
You need polarizing light/filter to see the congo red stain show the apple green color.
Beta pleaded structures form fibrils.
Physical Conformation — beta pleaded structure.
Congo red stain binds to meshwork of the beta pleaded structure.
