CILS: Accumulations and Adaptations

Question 1

T or F. Inclusion bodies due to viral infections can occur within the cytoplasmic space and can occur within nuclei?

Answer 1

True — Viruses need replication machinery present in the nucleus — Lead to Negri Bodies

Question 2

Herpes Virus builds up in both locations as well.

Answer 2

CMV — Cytomegalovirus— “Big Cell” — Owl’s Eye — or Cowdry Type A inclusions. — nuclear inclusions and granular

Question 3

Cellular Atypia is not a histopathologic feature of Dysplasia? T or F?

Answer 3

False

Question 4

All accumulations are the result of either a cell’s rate of production exceeding clearance or else the failure to metabolize an endogenous substance.

Answer 4

False — Coal Dust, Pollution, Melanoma

Question 5

Dysplasia is often a precursor to malignant transformation. T or F?

Answer 5

True

Question 6

With amyloidosis the heart liver or kindness are not common sites.

Answer 6

False

Question 7

A feature shared in common by both accumulations and adaptations is that both can arise from physiological and pathologic stimuli.

Answer 7

True

Question 8

Answer 8

Question 9

Answer 9

Both

Question 10

Answer 10

Cytomegalovirus

Question 11

Answer 11

Hypertrophy — “Box car Changes”

Question 12

Answer 12

Systolic

Question 13

Features of Dystrophic Calcification

Answer 13

Atrioventricular closing shut — lub

Aortic Valve and Pulmonary Artery Close — Dub

Lub Shuh Dub — Systolic Murmur — blood is having a hard time getting out of the ventricular chamber and into the aorta.

If you have dystrophic calcification it will have a hard time getting out of the aorta.

Question 14

Answer 14

Hyperplasia.

Lymphocyte hyperplasia which are reacting to some sort of infection.

Question 15

Answer 15

Prussian blue stains — stains iron.

Build up of iron in liver.

Question 16

Answer 16

High Ferritin associated with high total body Iron levels.

Longer Prothrombin time means blood is taking longer to clot than normal.

Liver makes clotting Factors

Question 17

Answer 17

Primary Hemochromatosis. (Answer) Inherited form — autosomal recessive — Genetic Form

Secondary Hemochromatosis — Multiple Transfusions — Iron buildup (sometimes called Hemosiderosis)

Hemosiderosis — There’s no anemia. Sometimes only refers Iron buildup as a result of macrophage activity.

Question 18

Answer 18

Excessive absorption of iron from the gastrointestinal tract.

Question 19

Answer 19

Cardiac Biopsy from a middle aged man.

Hypo-chromatic. Less organization.

Deposits of Amyloids.

Question 20

Question 21

Answer 21

You need polarizing light/filter to see the congo red stain show the apple green color.

Beta pleaded structures form fibrils.

Question 22

Answer 22

Physical Conformation — beta pleaded structure.

Congo red stain binds to meshwork of the beta pleaded structure.

Question 23

From among the following conditions the one responsible for the abnormalities seen in the photomicrographs seen in this conditions

Chronic Inflammation — rheumatoid arthritis

Aging

Plasma cell tumor that produces immunologlobulin light chain

A renal disease that requires chronic dialysis

Not able to be determined given the limited amount of information.

Answer 23

Not able to be determined given the limited amount of information. — Amyloid is produced by many different causes.

Question 24

They autopsy reveials calcium deposits presents in normal appearing lung and kidney tissues.

Answer 24

Parathyroid Adenoma

Question 25

Increase in the number of parenchymal cells

Answer 25

Hyperplasia

Question 26

Consequence of persistent hypercalcemia is:

Metastatic calcification

Atherosclerosis

Amyloidosis

Dystrophic calcification

Hemochromatosis

Answer 26

Metastatic calcification

Question 27

Most common form of pathologic calcium

Answer 27

Dystrophic type

Question 28

Organ most commonly involved in amyloidosis is the:

Kidney

Heart

Liver

Answer 28

Kidney — action where a lot of amyloid deposition occurs in the glomeruli.