Fibrous Proteins Flashcards by Omar Saqr

Q

Fibrous Protein

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Q

Collagen

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Collagen and Collagen Related Diseases

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What is the Pathology?

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Q

Pathology?

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Pathology?

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Pathology?

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Q

Mutation Underlying Osteogenesis Imperfecta

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Levels of Collagen Structure

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Collagen Role in Bone Formation

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Levels of Collagen Structure Models

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Collagen Primary Structure

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Q

Hydroxyproline

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Collagen Primary Structure and Interchain Hydrogen Bonding

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Model of Tripple Helix

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Stabilizing the Triple Helix

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Roles of Hydroxyproline

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Q

Collagen Synthesis

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Steps in Collagen Biosynthesis

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Function of Collagen Pro-Peptides

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Collagen Pro-Peptides

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Collagen Biosynthesis from transcription to formation

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Hydroxylation of Lysine

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Hydroxylation of Proline

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Why is Ascorbate acid essential in Collagen Biosynthesis

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Role of Hydroxyproline

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Lysine and Proline Hydroxylases

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Scurvy

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Cross-Link Formation in Collagen

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Post translational modification in lysine crosslink formation

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One type of Cross-Link Seen in Collagen

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Collagen Disorders

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Elastin

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What is Elastin

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Major differences between Collagen and Elastin

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Williams Syndrome and Supravalvular Aortic Stenosis

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Elastin Primary Structure

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Elastin Biosynthesis from transcription to formation

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Entropy Driven Elastic Recoil

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Elastin Open and Closed State

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Elastin Stretching the Limits

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Desmosine

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Building Elastin

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Fibrillin and Fibulin

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Fibrillin 1 Secretion

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Marfan’s Syndrome

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Conclusion

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