Cell Signaling Flashcards by Omar Saqr

Q

Objectives

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Overview of Signal Transduction

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Cellular Communication and the Cell Cycle

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Processes that Require Cell Signaling

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Cellular Communication and Energy Metabolism

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Cell Commuinication and Extracellular Environment

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Cellular Communication and Immune Defense

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Types of Chemical Messengers

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Neurotransmitters

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Hormones

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Cytokines

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Growth Factors

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Eicosanoids

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Retinoids

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Q

Signal Classification by Distance

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Endocrine

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Paracrine

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Autocrine

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Autocrine can be an abnormal process that cancer takes advantage of.

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Q

General Characteristics of Receptors

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Two Major Classes of Receptors

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Inttracellular Receptors

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Plasma Membrane Receptors

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Ion Channel Receptors

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Q

Similar features of Tyrosine Kinase, JAK-STAT, Serine Threonine Kinase Receptors

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Tyrosine Kinase Receptors

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JAK-STAT Receptors

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Serine-Threonine Kinase Receptors

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Tyrosine Kinase Features

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Epidermal Growth Factor

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Tyrosine Kinase Receptor

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Insulin Signaling

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Insulin Signaling and Glucose Uptake

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AKT and WTF?

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Tyrosine Kinase Receptor

Tyrosine Kinase — is more involved in cancer because it effects the cell cycle

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Features of Serine-Threonine Kinases

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TGF-Beta Receptors

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JAK STAT Receptors

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Heptahelical Receptors

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GPCR’s

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GPCR’s and CyclicAMP

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GPCR’s and IP3

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Ubiquitin

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Phosphatase

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GTPase

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G-Protein require the help of GAP proteins.

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Responding to a Receptor Requires…

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Ras and Ret

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Ras and Colon Cancer

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Colon Cancer Treatment Implications

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