Pharmacodynamics Part I

Question 1

General Features of Receptors

Answer 1

Question 2

Agonist Def.

Answer 2

Question 3

Antagonist Definition

Answer 3

Question 4

2 Critical Features of Receptors

Answer 4

Question 5

For almost all drugs the dose response curve is….

Answer 5

Question 6

Dose Response Curve for Almost All Drugs

Answer 6

Question 7

How does a dose response curve look when it’s in a semilog plot

Answer 7

Question 8

Plotting Equation for Linear or Semilog

Answer 8

Question 9

Def. of Potency

Answer 9

Question 10

Def. of Efficacy

Answer 10

Question 11

Relationship between Potency and Efficacy

Answer 11

Question 12

Alt Eqn for semilog or linear plot

Answer 12

Question 13

Values of Range of Binding/Response

Answer 13

Question 14

Answer 14

100 Fold

Question 15

Answer 15

Question 16

Dose Response Curve for 4 different Analgasic Drugs

Answer 16

Question 17

Explain the Potency and Efficacy of these 4 Drugs

Answer 17

Question 18

Explain this Graph

Answer 18

Question 19

Answer 19

Question 20

Cool Quote by Paracelsus

Answer 20

Question 21

Explain the Concept of Quantal Response

Answer 21

Question 22

Def and Eq. of Therapuetic Index

Answer 22

Question 23

Margin of Safety

Answer 23

Question 24

Doses that cause side effects…

Answer 24

Question 25

Plot of Therapuetic Index vs. MoS

Answer 25

Question 26

Aspirin: Therapuetic Effect, Side Effect, Lethality

Answer 26

Question 27

Answer 27

Question 28

Effect vs. Agonist

Answer 28

Question 29

Binding Vs. Agonist

Answer 29

Question 30

Answer 30

Question 31

Spare Receptors

Answer 31

Question 32

Advantages of Spare Receptors

Answer 32

Question 33

Spare Receptors and Proof of Less Desensitizaiton

Answer 33

Question 34

Spare Receptors and Greater Sensitivity

Answer 34

Question 35

Spare Receptors, Increased Sensitivity, and Drug Concentration

Answer 35

Question 36

Drug Binding and Dissociation Constant

Answer 36

Question 37

Lower Kd and Range

Answer 37

Question 38

Variability of on rates vs. off rates

Answer 38

Question 39

Answer 39

Question 40

Kd and Implications of choosing a drug

Answer 40

Question 41

Answer 41

Question 42

Efficacy and Potency for Partial and

Answer 42

Question 43

Efficacy of Partial Agonist vs. Full Agonist

Answer 43

Question 44

Proper dose of Partial agonist and baseline

Answer 44

Question 45

Lowering the Full Agonist Response

Answer 45

Question 46

Partial agonist intervention compared to full agonists or antagonists

Answer 46

Question 47

Buprenorphine

Answer 47

Question 48

Buprenorphine Response Curve

Answer 48

Question 49

Agonists, antagonists, and efficacy

Answer 49

Question 50

Can we account for full agonists, partial agonists, and antagonists with one simple model?

Answer 50

Question 51

R to R model

Answer 51

Question 52

R to R model of Action for agonists, partial agonists, antagonists, and reverse agonists

Answer 52

Question 53

Inverse Agonist

Answer 53

Question 54

Summary of Agonists, Partial Agonists, Antagonists, and Inverse Agonists

Answer 54