Generation of Diversity Flashcards by Omar Saqr | Brainscape

Q

A

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Clonal Selection

A

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

How many gene families are there?

A

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

How are V-Regions different in assembly than Constant Regions?

How are different regions coded for?

A

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Light Chain Gene Rearrangements

A

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Stepwise Light Chain Rearrangements:

Germline DNA

Rearranged DNA
Primary RNA Transcript

mRNA

PolyPeptide Chain

A

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Heavy Chain Rearrangments

A

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Stepwise Heavy Chain Rearrangements:

Germline DNA

Rearranged DNA
Primary RNA Transcript

mRNA

PolyPeptide Chain

A

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Heavy Chain Locus

A

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Kappa Light Chain Locus

A

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Lamda Light Chain Locus

A

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Heavy Chain Rearrangements in two different B-Cell Clones

A

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Immunoglobulin Heavy and Light Chain Loci

A

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Random Recombination of Gene Segments

A

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Junctional Diversity

A

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Schematic of V-J Recombination

A

Q

Junctional Diversity

A

Q

Potential Repitoire

A

Q

Diversity of CDR’s

A

Q

Allelic Exclusion

A

Q

Southern Blott

A

Q

PCR Primers

A

Q

Characterization of Junctional Genes

A

Q

When Does Somatic Hypermutation Occur?

A

Q

Somatic Hypermutation

A

Q

AID

A

Q

AID and the Process of Somatic Hypermutation

A

Q

Somatic Hypermutation and Secondary Response

A

Q

T-Cell Origin

A

Q

T-Cell Receptor vs. B-Cell

A

Q

Classes of T-Cell

A

Q

TCR Locus

A

Q

Recombination in T-Cells

A

Q

RAG Deficiency

A

Q

TCR Junctional Diversitu

A

Q

TCell Repitoire

A

Q

A

Light Chain DNA Gene Rearrangement

(Only heavy chains undergo class switching) B is the answer