Generation of Diversity Flashcards by Omar Saqr

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Clonal Selection

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How many gene families are there?

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How are V-Regions different in assembly than Constant Regions?

How are different regions coded for?

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Light Chain Gene Rearrangements

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Stepwise Light Chain Rearrangements:

Germline DNA

Rearranged DNA
Primary RNA Transcript

mRNA

PolyPeptide Chain

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Heavy Chain Rearrangments

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Stepwise Heavy Chain Rearrangements:

Germline DNA

Rearranged DNA
Primary RNA Transcript

mRNA

PolyPeptide Chain

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Heavy Chain Locus

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Kappa Light Chain Locus

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Lamda Light Chain Locus

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Heavy Chain Rearrangements in two different B-Cell Clones

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Immunoglobulin Heavy and Light Chain Loci

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Random Recombination of Gene Segments

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Junctional Diversity

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Schematic of V-J Recombination

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Junctional Diversity

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Potential Repitoire

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Diversity of CDR’s

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Allelic Exclusion

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Southern Blott

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PCR Primers

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Characterization of Junctional Genes

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When Does Somatic Hypermutation Occur?

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Somatic Hypermutation

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AID

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AID and the Process of Somatic Hypermutation

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Somatic Hypermutation and Secondary Response

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T-Cell Origin

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T-Cell Receptor vs. B-Cell

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Classes of T-Cell

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TCR Locus

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Recombination in T-Cells

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RAG Deficiency

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TCR Junctional Diversitu

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TCell Repitoire

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Light Chain DNA Gene Rearrangement

(Only heavy chains undergo class switching) B is the answer