Nucleic Acids Pt. II Flashcards by Omar Saqr

Q

Adenosine Degredation

A

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Guanosine Degredation

A

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Treatments for Gout

A

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Uricase

A

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Xanthine Oxidase

A

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Gout: Hyperuricemia

A

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Lesch Nyhan Syndrome

A

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Adenosine Deaminase Deficiency

A

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

PNP Deficiency

A

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Carbon Sources for Pyrimidine

A

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Pyrimidine Biosynthesis

A

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Which one of the following is a precursor for both purine and pyrimidine biosynthesis?

PRPP

Aspartate

Ammonia

Glycine

Carbon Dioxide

A

Which one of the following is a precursor for both purine and pyrimidine biosynthesis?

PRPP

Aspartate — Donates Nitrogen on carbon 1

Ammonia

Glycine

Carbon Dioxide

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Dihydroorotate Synthesis

A

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

UMP Synthesis

A

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Synthesis of UTP and CTP

A

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

The UTP to CTP reaction is similar to:

Imp to AMP

IMP to CMP

IMP to XMP

XMP to GMP

XMP to UMP

A

The UTP to CTP reaction is similar to:

Imp to AMP

IMP to CMP

IMP to XMP

XMP to GMP — Requires Glutamine as a Nitrogen Source

XMP to UMP

Q

Biosynthesis of Deoxyribonucleotides

A

Q

Regulation of Ribonucleotide Reductase

A

Q

Preferred Substrate

Effector at Overall Activity Site

Effector at Substrate Specificity Site

A

Q

Ribonucleotide Reductase Rationale for Regulation

A

Q

Synthesis of dTMP

A

Q

Thymidylate Synthase

A

Q

Adensoine Deaminase Deficiency

A

Q

Pyrimidine Base Salvage

A

Q

Pyrimidine Catabolism

A

Q

Hereditary Orotic Aciduria

A

Q

One Carbon Metabolism

A

Q

Tetrahydrofolate

A

Q

Why are folates important?

A

Q

Folate Analogs

A

Q

How do Folate Analogs kill Dividing Cells?

A

Q

Azaserine

A

Q

5-Flourouracil

A

Q

Methotrexate

A

Q

People with G6PDH deficiency shouldn’t take Sulfonamide.

Which one of the pathways would not be inhibited by Azaserine?

Inosine Biosynthesis

Orotic Acid Biosynthesis

GMP Synthesis from IMP

AMP Synthesis from IMP

CTP Synthesis from UTP

A

People with G6PDH deficiency shouldn’t take Sulfonamide.

Which one of the pathways would not be inhibited by Azaserine?

Inosine Biosynthesis

Orotic Acid Biosynthesis

GMP Synthesis from IMP

AMP Synthesis from IMP — Requires aspartate instead, every other pathway requires glutamine.

CTP Synthesis from UTP

Q

Case Study

A

Adenosine Deaminase Deficiency — Deoxyadensine accumulates and causes problems.