Pharmacokinetics Pt. II Flashcards by Omar Saqr

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Pharmacokinetics Pt. II

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Q

Equations in Pharmacokinetics Pt. II

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Start of Infusion and Wash Out

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Continuous Infusion

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T1/2 and Final Destination

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Relationship between steady state concentration and infusion rate

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Steady State

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What was wrong with this Problem

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What does approaching Steady State Depend on?

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Q

Loading Dose

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Advantages/Disadvantages of Loading Dose

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Discontinous Dosing

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Variation in Drug Concentration with Dosing Interval

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Tau vs. [Steady State Min]/[Steady State Max]

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Average Steady State Concentration During Intermittent Dosing

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Tau vs. Swings in [Drug]

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Goals in Adjusting Dosing Regimen

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Case I: High Therapuetic Index and Intermediate t1/2

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Case II: t1/2 is long (>24hrs)

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Case III: Short t1/2 or low Therapuetic Index

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Calculate K0 and Dl

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Variation in Clearance and Vd from Patient to Patient

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