Pharmacokinetics Pt. II Flashcards

1
Q

Pharmacokinetics Pt. II

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2
Q

Equations in Pharmacokinetics Pt. II

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3
Q

Start of Infusion and Wash Out

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4
Q

Continuous Infusion

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5
Q

T1/2 and Final Destination

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6
Q

Relationship between steady state concentration and infusion rate

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7
Q

Steady State

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8
Q

What was wrong with this Problem

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9
Q

What does approaching Steady State Depend on?

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10
Q

Loading Dose

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11
Q

Advantages/Disadvantages of Loading Dose

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12
Q

Discontinous Dosing

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13
Q

Variation in Drug Concentration with Dosing Interval

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14
Q

Tau vs. [Steady State Min]/[Steady State Max]

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15
Q

Average Steady State Concentration During Intermittent Dosing

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16
Q

Tau vs. Swings in [Drug]

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17
Q

Goals in Adjusting Dosing Regimen

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18
Q

Case I: High Therapuetic Index and Intermediate t1/2

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19
Q

Case II: t1/2 is long (>24hrs)

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20
Q

Case III: Short t1/2 or low Therapuetic Index

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21
Q
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22
Q

Calculate K0 and Dl

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23
Q
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24
Q

Variation in Clearance and Vd from Patient to Patient

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