Protein Folding, Structure, and Function

Question 1

Function and Roles of Proteins

Answer 1

Question 2

Proteins fail to fold Correctly

Answer 2

Question 3

Protein is not stable enough to preform its normal function

Answer 3

Question 4

Fails to be correctly trafficked

Answer 4

Question 5

Diseases of insolube aggregates

Answer 5

Question 6

Cellular Consequences of Protein Aggregation

Answer 6

Question 7

Relevant Protein Folding Diseases

Answer 7

Question 8

Protein Structure and Folding

Answer 8

Question 9

Monomeric Protein Subunits:

Variety

Diversity

Answer 9

Question 10

Calculating # of possible sequences in proteins

Answer 10

Question 11

Generalized Amino Acids

Answer 11

Question 12

Amino Acids basic structure and L vs. D distinction

Answer 12

Question 13

Non-Polar Aliphatic AA’s

Answer 13

Question 14

Aromatic Amino Acids

Answer 14

Question 15

Polar Uncharged AA’s

Answer 15

Question 16

Sulfur Containing

Answer 16

Question 17

Charged AA’s

Answer 17

Question 18

Short Names of AA’s

Answer 18

Question 19

Sulfur Containing Amino Acid Interactions

Answer 19

Question 20

Amino Acid Side Chain Ionizations

Answer 20

Question 21

Globular Proteins

Answer 21

Question 22

Fibrous Proteins

Answer 22

Question 23

Transmembrane Proteins

Answer 23

Question 24

Primary Level of Globular Protein Structure

Answer 24

Question 25

Secondary Level of Globular Protein Structure

Answer 25

Question 26

Tertiary Level of Globular Protein Structure

Answer 26

Question 27

Quaternary Level of Globular Protein Structure

Answer 27

Not all proteins have Quaternary Structures.

Hemoglobin is a tetramer

Myoglobin is a monomer

Question 28

Peptide Bond Formation

Answer 28

Question 29

Amino Acids are linked by?

Answer 29

Question 30

Geometry of Peptide Bonds

Answer 30

Question 31

Primary sequence determines?

Answer 31

Question 32

Components of Secondary Structure

Answer 32

Question 33

The Alpha Helix

Answer 33

Question 34

Identifying the Helix Type

Answer 34

Question 35

Beta Sheets

Answer 35

Question 36

The Beta Sheet

Answer 36

Question 37

The Reverse Turn

Answer 37

Question 38

Tertiaruy Structure includes all…

Answer 38

Question 39

Protein Diversity

Answer 39

Question 40

Solubility of Globular Proteins

Answer 40

Question 41

Quaternary Structure

Answer 41

Question 42

2 Examples of Proteins with Quaternary Structure

Answer 42

Question 43

Protein Protein Interactions

Answer 43

Question 44

Answer 44

Question 45

Entropy of Polypeptide chain favors…

Answer 45

Question 46

Major Force Resonsible for Folding

Answer 46

Question 47

As Protein Increases Size…

Answer 47

Question 48

Native State Stabilization

Answer 48

Question 49

Molecular Chaperones

Answer 49

Question 50

Protein Misfolding Diseases

Answer 50

Question 51

Prion Diseases

Answer 51

Question 52

Difference between PrPc and PrPsc

Answer 52

Question 53

Prion Conformational Change

Answer 53

Question 54

Conformational Differences

Answer 54

Question 55

Model of Protein Misfolding and Propagation

Answer 55

Question 56

Protein Misfolding Diseases

Answer 56

Question 57

A closer look at Amyloidoses

Answer 57

Question 58

Causes of formation of Amyloid Fibrils

Answer 58

Question 59

Mechanism of Amyloid Fibril Formation

Answer 59

Question 60

Amyloid Fibril Fomration Cont.

Answer 60

Question 61

Consequences of Amyloid Fibril Formation

Answer 61

Question 62

Therapeutic Approaches to Amyloid Fibril Formation

Answer 62