Drug Absorption Pt. II

Question 1

Trapping a Weakly Basic

Answer 1

Question 2

Henderson Hasselbach Equation

Answer 2

Question 3

Where is Aspirin, a weak acid, absorbed and why?

Answer 3

Question 4

Where is a Chlorodiazepoxide, a weak base, absorbed and why?

Answer 4

Question 5

ADME graph at different pH’s

Answer 5

Question 6

Observations on Drug administration and compartmentalization

Answer 6

Question 7

Examples of Compartments

Answer 7

Question 8

pH of Selected Body Fluids

Answer 8

Question 9

Answer 9

Question 10

Quantitative Drug Distribution Problems

Answer 10

Question 11

Definition of Acid/Base

Answer 11

Question 12

Answer 12

Question 13

Answer 13

Question 14

Ibuprofin

(Weak Acid pKa = 4.4)

Answer 14

Question 15

Where will Ibuprofin be efficiently absorbed?

Answer 15

Question 16

Drug Partitioning Problems for Weak Acids

Answer 16

Question 17

Drug Partioning Problems for Weak Bases

Answer 17

Question 18

Special Case of weak acid with very basic PKa

or

Weak Base with very acidic PKa

Answer 18

Question 19

Adjusting pH to trap drug in urine

Answer 19

Question 20

Answer 20

Question 21

Adjusting Urine pH and effect on Clearance for weak acids

Answer 21

Question 22

Adjusting pH and Clearance of Weak Bases

Answer 22

Question 23

Real World Example of Drug Clearance

Answer 23

Question 24

Answer 24

None of the Above

Question 25

Answer 25

4

Question 26

Answer 26

Option #4

Question 27

Answer 27

Option 3

Question 28

Answer 28

Option 4

Question 29

Answer 29

Option 6

Question 30

Answer 30

Option 1

Question 31

Answer 31

Option 2 (0.1)

Question 32

Answer 32

Option 3 (1)

Question 33

Answer 33

Figure it out

Question 34

Answer 34

?

Question 35

Answer 35

Figure it out