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Fundamentals of Molecular Medicine > Review > Flashcards

Review Flashcards

1
Q
A
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2
Q

Carbon use in THF

A
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3
Q

Synthesis of PRPP

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4
Q

Committed Step of Purine Synthesis

Name of Enzyme

How is it Regulated

Reactants/Substrates/Products

A
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5
Q

IMP to AMP

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6
Q

Biosynthesis of GMP

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7
Q

GMP to GDP

and AMP to ADP

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8
Q

Regulation of DeNovo Purine Synthesis

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9
Q

What leads to overproduction of Purines

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10
Q

Purine Salvage

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11
Q

Purine Nucleotide Cycle

A
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12
Q

Adensoine Degredation

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13
Q

Guanosine Degredation

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14
Q

Uricase

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15
Q

Xanthine Oxidase

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16
Q

Purine Metabolism Defects

A
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17
Q

Carbon Sources for Pyrimidine

A
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18
Q

DeNovo Pyrimidine Synthesis

A
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19
Q

Pyrimidine Synthesis Continued

A
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20
Q

CTP Synthetase

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21
Q

Reduction of Ribonucleotides

A
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22
Q

Ribonucleotide Reductase Regulation

A

2 Allosteric Sites one substrate Specificity and the other Overally activity

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23
Q

dTMP Synthesis

A
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24
Q

Adenosine Deaminase Deficiency Revisited

A
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25
Q

Pyrimidine Base Salvage

A
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26
Q

Hereditary Orotic Aciduria

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27
Q

Importance of Folate

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28
Q

Folate Analogs

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29
Q

How does folate kill rapidly dividing cells

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30
Q

One Carbon Metabolism Revisited

A
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31
Q

Primary vs. Secondary Immune Response

A
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32
Q

Opsonization

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33
Q
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34
Q

Fetal Immunoglobulins

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35
Q

IgM vs. IgG Affinity Maturation

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36
Q

Two Types of Opsonization

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37
Q

4 Effector Functions of Neutralization

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38
Q

IgE

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39
Q

Affinity vs. Avidity

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40
Q

Ag-Ab Immune Complex

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41
Q

Antibody Titer

A
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42
Q

Elisa

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43
Q

Western Blot

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44
Q

Agglutination

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45
Q

Hemolytic Disease of the Newborn

A
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46
Q

Direct vs Indirect Coombs Test

A
47
Q

Rhogam

A
48
Q

Sporadic, Familial, Hereditary

A
49
Q

CML vs. ALL Neoplasia

A
50
Q

PARP Inhibitors

A
51
Q

Beta Catenin and APC

A
52
Q

NF1 Mutation

A
53
Q

Genetics of Basal Cel Carcinoma

A
54
Q

Nevoid Basal Cell Carcinoma

A
55
Q

Vismodegiv

A
56
Q

Familial Melanoma

A
57
Q

Caclium Absorption

A
58
Q

Regulation of Plasma Calcium

A
59
Q

Osteoporosis and Hypercalcemia

A
60
Q

Iron Absorption

A
61
Q

Reduction and Enhancement of Iron Absorption

A
62
Q

Iron Deficiency

A
63
Q

Hemochromatosis

A
64
Q

Roles and Dietary Sources of Magnesium

A
65
Q

Magnesium Deficiency and Toxicity

A
66
Q

Light Chain and Heavy Chain Rearrangement

A
67
Q

How many times do Heavy Chains Undergo Somatic Recombination compared to Light Chains

A
68
Q

RAG

A
69
Q

Junctional Diversity

A
70
Q

T-Cell Repitoire vs. Ig Repitoire

A
71
Q

Allelic Exclusion

A
72
Q

Somatic Hypermutation

(Not Somatic Recombination)

A
73
Q

AID

A
74
Q

T-Cell Features

A
75
Q

Somatic Recombination vs. Somatic Hypermutation in Ig vs. TCR

A
76
Q

Life Cycle of Listeria Monocytogenes

A
77
Q

MHC Class II Processing

A
78
Q

MHCI Processing

A
79
Q

Viral Inhibitors of MHC Class I

A
80
Q

Immune Adherence

A
81
Q

Anaphyatoxins

A
82
Q

Roles of Complement

A
83
Q

Complement Pathway

A
84
Q

Classical Pathway

A
85
Q

Classical vs. Alternate vs. Lectin Pathway

A
86
Q

Alternate Pathway

A
87
Q

DAF and C1 Esterase Inhibitor

A
88
Q

Enrichement vs. Fortification

A
89
Q

Role of Beta Carotine

A
90
Q

Vitamin A Deficiency

A
91
Q

Water Soluble Vitamins

A
92
Q

Fat Soluble Vitamins

A
93
Q

Sensitivity vs. Specificity

A
94
Q

Positive/Negative Predictor Value

A
95
Q

Exome Sequencing

A
96
Q

Expression of MHC I vs. MHC II

A
97
Q

HLA MHC II region

A
98
Q

MHC binding Domain vs. Ig Binding Domain

A
99
Q

MHC Restriction

A
100
Q

of MHC I vs. MHCII expressed

A
101
Q

MHC Pockets

A
102
Q

Codominant Expression

A
103
Q

Lysosome Formation

A
104
Q

Ubiquitination

A
105
Q

Ring vs. Hect

A
106
Q

Proteosome Structure

A
107
Q

Regulation of Proteosome

A
108
Q

Macronutrient Distribution

A
109
Q

PLasma LDL Levels

A
110
Q

Streptococcus Thermophilus

A
111
Q

S. Pyogenes

A
112
Q

Cas9 Specificity

A
113
Q

Non-Homologous End Joining

A

Fundamentals of Molecular Medicine (77 decks)

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