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Fundamentals of Molecular Medicine > Review > Flashcards

Review Flashcards

1
Q
A
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2
Q

Carbon use in THF

A
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3
Q

Synthesis of PRPP

A
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4
Q

Committed Step of Purine Synthesis

Name of Enzyme

How is it Regulated

Reactants/Substrates/Products

A
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5
Q

IMP to AMP

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6
Q

Biosynthesis of GMP

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7
Q

GMP to GDP

and AMP to ADP

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8
Q

Regulation of DeNovo Purine Synthesis

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9
Q

What leads to overproduction of Purines

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10
Q

Purine Salvage

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11
Q

Purine Nucleotide Cycle

A
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12
Q

Adensoine Degredation

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13
Q

Guanosine Degredation

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14
Q

Uricase

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15
Q

Xanthine Oxidase

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16
Q

Purine Metabolism Defects

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17
Q

Carbon Sources for Pyrimidine

A
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18
Q

DeNovo Pyrimidine Synthesis

A
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19
Q

Pyrimidine Synthesis Continued

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20
Q

CTP Synthetase

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21
Q

Reduction of Ribonucleotides

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22
Q

Ribonucleotide Reductase Regulation

A

2 Allosteric Sites one substrate Specificity and the other Overally activity

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23
Q

dTMP Synthesis

A
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24
Q

Adenosine Deaminase Deficiency Revisited

A
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25
Q

Pyrimidine Base Salvage

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26
Q

Hereditary Orotic Aciduria

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27
Q

Importance of Folate

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28
Q

Folate Analogs

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29
Q

How does folate kill rapidly dividing cells

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30
Q

One Carbon Metabolism Revisited

A
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31
Q

Primary vs. Secondary Immune Response

A
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32
Q

Opsonization

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33
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34
Q

Fetal Immunoglobulins

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35
Q

IgM vs. IgG Affinity Maturation

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36
Q

Two Types of Opsonization

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37
Q

4 Effector Functions of Neutralization

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38
Q

IgE

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39
Q

Affinity vs. Avidity

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40
Q

Ag-Ab Immune Complex

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41
Q

Antibody Titer

A
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42
Q

Elisa

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43
Q

Western Blot

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44
Q

Agglutination

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45
Q

Hemolytic Disease of the Newborn

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46
Q

Direct vs Indirect Coombs Test

47
Q

Rhogam

48
Q

Sporadic, Familial, Hereditary

49
Q

CML vs. ALL Neoplasia

50
Q

PARP Inhibitors

51
Q

Beta Catenin and APC

52
Q

NF1 Mutation

53
Q

Genetics of Basal Cel Carcinoma

54
Q

Nevoid Basal Cell Carcinoma

55
Q

Vismodegiv

56
Q

Familial Melanoma

57
Q

Caclium Absorption

58
Q

Regulation of Plasma Calcium

59
Q

Osteoporosis and Hypercalcemia

60
Q

Iron Absorption

61
Q

Reduction and Enhancement of Iron Absorption

62
Q

Iron Deficiency

63
Q

Hemochromatosis

64
Q

Roles and Dietary Sources of Magnesium

65
Q

Magnesium Deficiency and Toxicity

66
Q

Light Chain and Heavy Chain Rearrangement

67
Q

How many times do Heavy Chains Undergo Somatic Recombination compared to Light Chains

69
Q

Junctional Diversity

70
Q

T-Cell Repitoire vs. Ig Repitoire

71
Q

Allelic Exclusion

72
Q

Somatic Hypermutation

(Not Somatic Recombination)

74
Q

T-Cell Features

75
Q

Somatic Recombination vs. Somatic Hypermutation in Ig vs. TCR

76
Q

Life Cycle of Listeria Monocytogenes

77
Q

MHC Class II Processing

78
Q

MHCI Processing

79
Q

Viral Inhibitors of MHC Class I

80
Q

Immune Adherence

81
Q

Anaphyatoxins

82
Q

Roles of Complement

83
Q

Complement Pathway

84
Q

Classical Pathway

85
Q

Classical vs. Alternate vs. Lectin Pathway

86
Q

Alternate Pathway

87
Q

DAF and C1 Esterase Inhibitor

88
Q

Enrichement vs. Fortification

89
Q

Role of Beta Carotine

90
Q

Vitamin A Deficiency

91
Q

Water Soluble Vitamins

92
Q

Fat Soluble Vitamins

93
Q

Sensitivity vs. Specificity

94
Q

Positive/Negative Predictor Value

95
Q

Exome Sequencing

96
Q

Expression of MHC I vs. MHC II

97
Q

HLA MHC II region

98
Q

MHC binding Domain vs. Ig Binding Domain

99
Q

MHC Restriction

100
Q

of MHC I vs. MHCII expressed

101
Q

MHC Pockets

102
Q

Codominant Expression

103
Q

Lysosome Formation

104
Q

Ubiquitination

105
Q

Ring vs. Hect

106
Q

Proteosome Structure

107
Q

Regulation of Proteosome

108
Q

Macronutrient Distribution

109
Q

PLasma LDL Levels

110
Q

Streptococcus Thermophilus

111
Q

S. Pyogenes

112
Q

Cas9 Specificity

113
Q

Non-Homologous End Joining

Fundamentals of Molecular Medicine (77 decks)

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