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Fundamentals of Molecular Medicine > Cell Movement and the Cytoskeleton > Flashcards

Cell Movement and the Cytoskeleton Flashcards

1
Q

Objectives

A
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2
Q

Why should a physician care about cell movement

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3
Q

The Cytoskeleton

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4
Q

Cytoskeletal Proteins

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5
Q

Cytoskeletal Functions

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6
Q

What is the green?

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7
Q

What are Microtubules

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8
Q

Microtubule Structure

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9
Q

Video of Microtubules

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10
Q

Lysosomes and Endosomes Revisited

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11
Q

Kinesins vs. Dyneins

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12
Q

Centrioles

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13
Q

Mitotic Spindle

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14
Q

Name 3 Drugs that Affect Microtubule function

A
  1. Colchicine
  2. Vinblastine
  3. Taxol
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15
Q

Colchicine

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16
Q

Vineblastine

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17
Q

Taxol

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18
Q

Cilia Structure and Function

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19
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20
Q

Primary Cilliary Dyskinesia

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21
Q
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22
Q

Microfilament Structure

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23
Q

Polymorphism of Microtubules

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24
Q

Microfilaments and Cytoskeleton

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26
Q

Microvilli vs. Cillia

A

Microvilli — shorter than cilia and immobile. Their core protein of Microfilaments

Cilia — core protein of microtubules — actively moved by the cell

27
Q

Cell Division and Microtubules vs. Microfilaments

28
Q

Name 2 Drugs that Affect Microfilament Function

29
Q

Cytochalasins

30
Q

Phalloidin

31
Q

Intermediate Filaments Structure and Function

32
Q

Type I intermediate Filaments

33
Q

Type II Intermediate Fillaments

34
Q

Type III Intermediate Filaments

35
Q

Type IV Intermediate Filaments

36
Q

Type V Intermediate Filaments

37
Q

Intermediate Filaments and Structural Integrity

39
Q

Skin Cells Stained for Keratin

40
Q

Epidermolytic Bullosa Simplex (EBS)

41
Q

EBS Mutation

42
Q

Epidermolytic Hyperkeratosis

43
Q

Epidermolytic Palmoplantar Keratoderma

44
Q

Hypertrophic Cardiomyopathy

45
Q

Motor Neuron Disease

46
Q

NF-H Overexpression

47
Q

Taxol is used to treat which of the following?

Broken Bones

Cancer

Atrophy of Muscle

Viral Infections

Bacterial Infections

48
Q

Which of these are involved in chromosome movement during mitosis and meiosis?

Microtubules

Intermediate filaments

Microfilaments

A

Microtubules

49
Q

Which of these are involved in cytokinesis?

Microtubules

Intermediate filaments

Microfilaments

A

Microfilaments

50
Q

What is the diameter and polarity of microtubules?

50nm Plar

50 nm Non polar

25nm Polar

A

25nm Polar

51
Q

Which is true regarding cytoskeletal Elements and subunits?

Most cytoskeletal proteins are part of the network

Most cytoskeletal proteins are soluble subunits

There is a balance between network and soluble subunits in the cell.

A

There is a balance between network and soluble subunits in the cell.

52
Q

Cytoskeletal elementas have a wide variety of functions much of this variety of function can be explained by?

Different core subunits in each element

Polarity of each element

The protein associated with each element

Availability of ATP to each Element

A

The protein associated with each element

53
Q

Genetic defects in keratin genes leads to which of the following?

Cardiomyopathy

Mental Retardation

Hepatitis

Early onset diabetes

Skin blistering of newborns

A

Skin blistering of newborns

54
Q

If you had a sample of tumor from a patient and whereintereste in knowing the origin of the tumor cells an antibody to which protein family would be most helpful?

Microtubules

Intermediate Filaments

Microfilaments

A

Intermediate Filaments

55
Q

Which of these are the “Tracks” on which cellular vesicles travel?

Microtubules

Intermediate Filaments

Microfilaments

A

Microtubules

56
Q

What is the diameter and polarity of intermediate filaments?

10 nm Polar

10nm Non Polar

A

10nm Non Polar

57
Q

Which of the following describing the microtubule organizing center is correct?

Near golgi associated with the minus end of microtubules

Near golgi associated with the plus end

Near nucleus associated with the minus end of the microtubules

Near the nucleus associated with the plus end of the microtubules

A

Near golgi associated with the minus end of microtubules

58
Q

In this image green is staining for tubular the red dot is which of the following?

Centriole

Filopdia

Mitochondria

The endoplasmic reticulum

59
Q

What is the diameter and polarity of microfilaments?

60
Q

Which of the following forms the core protein in cillia

Microtubules

Intermediate Filaments

Microfilaments

A

Microtubules

Fundamentals of Molecular Medicine (77 decks)

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