Test 87: All Flashcards
What does human multi drug resistance ( MDR1) gene code for
P-glycoprotein: transmembrane ATP-dependent efflux pump protein that has a broad specificity for hydrophobic compounds
Tumor cell lines become resistant after exposure to various anticancer agents. These cells express a specific cell surface glycogprotein that functions how
- ATP-depenent transporter
Individuals who are successfully immunized against hep B virus develop protective
anti-HBs antibody
Individuals who recover from Hep B infection have what
- anti HBs
- anti- HBc
Human epidermal growth factor receptor 2 (HER2) is what type of receptor
tyrosine kinase receptor
What drug targets HER2
Trastuzumab
drug that is VEGF inhibitor
Bevacizumab
MOA for Denosumab
human monoclonal antibody against RANKL
What nerve causes weakness perineal musculature causing fecal and urinary incontinence, perineal pain , and sexual dysfunction?
Pudendal nerve injury
What is the root for the pudendal nerve
S2,3,4 keeps the penis off the floor
Where does the pudendal nerve reenter the pelvis
near ischial spine
Masculization of female infant with increased testosterone and androstenedione. Mother has virilization during pregnancy
aromatose deficiency
Trauma or sustained pressure to the neck of fibula can cause injury to what nerve
common peroneal nerve
MOA for Etanercept
TNF-alpha decoy
Elevated systemic blood pressure from alpha1 adrenergic agnonists does what to the heart
- increase vagal tone
- decrease heart rate
- flow AV node conduction
Piperacillin-tazobactam is effective against what
- gram (-) enteric rods
- bacteroides fragilis
Name Beta-lacatmase inhibitors
CAST
- Clavulanic Acid
- Sulbactam
- Tazobactam
Patient’s EKG was irregularly irregular with absent P waves suggetst
atrial fibrillation
Bone pain and elevated alkaline phosphatase level in an elderly patient can occur with what
- osteoblastic metastases
2. paget disease of bone
Potter sequence
- renal anomaly
- oligohydramnios
- compression of fetus
- pulmonar hypoplasia
What provides the fastest reversal of Warfarin effects
fresh frozen plasma
Can you give a patient with INR above 3 warfarin therapy
no
What is used for heparin reversal
protamine
What does cryoprecipitate contain
- cold-soluble proteins ( factor 8, fibrinogen, von Willebrand factor, vitronectin )
Where is water always impeccable in kidney
ascending limb of loop of henle
Most common indolent non-Hodgkin lymphoma in adults
follicular lymphoma
How does follicular lymphoma present
“waxing and waning” lymphadenopathy
Patient with persistent fluctuating lymphadenopathy, who may have had an unrelated pharyngitis ( treated with antibiotics) on initial presentation, most likely has
follicular lymphoma
Follicular lymphoma is derived from what type of cell
follicular B cell
Translocation for follicular lymphoma
14:18
over expression of bcl-2
psoas sign
pain is exacerbated by extension of the hip
KRAS is what type of cancer gene
Proto-oncogene
type of cancer gene APC
tumor suppressor
type of gene BRACA1
tumor suppressor gene
Type of gene RB
tumor suppressor gene
Type of gene TP53
tumor suppressor gene
