Test 81: All Flashcards

1
Q

5 day old newborn: multiple episodes of emesis, fewer breastfeedings, fewer wet diapers. Tachycardia, tachypnea, hypotension. Icteric lethargic baby with shrunken fontanelle, dry mucous membranes, and hepatomegaly. Heme studies show leukocytosis with bandemia. Hypoglycemia and elevated transaminases. Ammonia is normal. Atrial blood culture shows gram-negative rods

A

Galactosemia

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2
Q

What is wrong in galactosemia

A

galactose-1-phosphate uridyltransferase

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3
Q

treatment for galactosemia

A
  • exclude galactose and lactose from diet

- switch to soy based formula

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4
Q

what does galactose-1-phosphate urdyltransferase convert

A

Galactose-1-P to Glucose-1-P

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5
Q

What does Staph. Epidermis produced

A
  • adherent biofilms,

- extracellular polysaccharide matrix

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6
Q

most potent type of diuretic

A

loop diuretic

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7
Q

Loop and thiazide diuretics can cause what same side effects

A
  • hypokalemia

- metabolic alkalosis

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8
Q

Who is more likely to get hyponaturemia loop or thiazaides

A

Thiazides

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9
Q

Which one is likely to cause hypercalcemia: thiazide or loop

A

thiazide

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10
Q

Renal drug that can cause metabolic acidosis in addiction to natriuresis

A

Acetazolamide

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11
Q

Renal drugs that can cause hyperkalemia and metabolic acidosis

A

Amiloride and Spironolactone

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12
Q

An increase in the activity of enzymes responsible for DNA synthesis signifies that the cell is in what phase

A

S phase

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13
Q

Role of Retinoblastoma (Rb) protein regulates what

A

G1 to S phase transition

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14
Q

What forms is Rb present in

A

Active: hypophosphorylated
inactive: hyperphosphoralted

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15
Q

What hyperphosphorylates Rb protein

A

Cycln D, E

CDK4,6

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16
Q

Hyperphosphorylated Rb releases what

A

E2F transcription factor ( allows cells to progress through cycle)

17
Q

What dos hypophophorylated Rb bind to

A

E2F transcription factor,

- complex inhibits transcription of genes

18
Q

RAS protein is apart of what

A

MAP-kinase signal

19
Q

p27

A

protein cell cycle inhibitor

- during G1 phase

20
Q

MOA for Minoxidil

A

Direct arteriolar vasodilator

21
Q

what is Minoxidil used for

A
  • androgenetic alopecia

- severe refractory hypertension

22
Q

Arteriolar vasodilators can have what type of reflux

A
  • Sympathetic activation: tachycardia

- Renin-angioteninsin-Aldosteroe : sodium and fluid retention

23
Q

How does a complete mole form

A

empty ovum is fertilized by haploid sperm

- duplicate paternal genetic complement

24
Q

Does complete mole contain fetal parts

A

no

25
Q

how does a 46 XX complete mole form

A

Empty ovum with duplicated sperm

26
Q

how does 46XY complete mole form

A

2 sperm with empty ovum

27
Q

Child presents with long, narrow face, a prominent chin and forehead and large testes. what does the child most likely ahve

A

Fragile X syndrome

28
Q

Ehlers-Danlos is a defective production of what

A

type V collagen

29
Q

What causes Prader-Willi syndrome

A

imprinting

- paternal deletion of part of chromosome 15

30
Q

When do you screen pregnant women for strep. agalactiae

A

35-37 weeks gestation

31
Q

What is the treatment for strep. agalactiae

A

INTRAPARTUM antibiotics ( penicillin or ampicillin)