Test 76: Derm Flashcards
Hansen disease infects what organs
skin and nerves
Infection of Hansen disease can be associated with contact with what
Armadillo
Difference b/w Tuberculoid leprosy and Lepromatous leprosy
Tuberculoid: Th1 immune
Lepromatous: Th2, lethal
Merocrine glands release what
watery security product via exocytosis with no loss of cell membrane
Apocine glands secrete
membrane-bound vesicles containing the secretory product
Holocrine galnds release
entire content of cells via cell lysis
What type of glands are involved with acne
Sebaceous gland which is a type of holocrine gland
Exposure to what rays causes photoaging
UVA
What happens in photo aging of skin
- epidermal atrophy
- flattening rete ridges
- decrease collagen fibril production
- increase degradation of collagen and elastin in dermis
- increase cross-linking of collagen
Axillary lymph node dissection is a risk factor for the development of what?
Chronic lymphadema involving the ipsilateral arm
- predisposes to angiosarcoma
Stewart-Treves Syndrome
angiosarcoma
What is Cherry Hemangioma
- Benign capillary hemangioma of elderly
- Does not regress
- frequency increases with age
What is strawberry hemangioma
- Benign capillary hemangioma of infancy
How does strawberry hemangioma present
- appears first few weeks of life
- grows rapidly
- regresses spontaneously by 5-8 years
4 year old caucasion male has recurrent skin and respiratory infections. Light skin and silvery hair. Horizontal nystagmus. Peripheral blood smear: giant cytoplasmic granules in neutrophils and monocytes
Chediak-Higashi syndrome
Wiskott-Aldrich syndrome
- Eczema, thrombocytopenia
- combined B and T disorder
Chediak-Higashi syndrome is a defect in what
neutrophil phagosome lysosome fusion
Poison ivy dermatitis produces what in skin
Urushiol
- causes immune response
Androgenetic alopecia causes hair loss primarily where on head
anterior scalp and vertex
What is the main pathogenic factor for androgenetic alopecia
Dihydrotestosterone (DHT)
MOA for Finasteride
5alpha reductase inhibitor
Inheritance pattern for androgenetic alopecia
Polygenic inheritance
What is used to treat alopecia areta
intralesional glucocorticoids
Terbinafina is used to treat what
Tinea capitis
Most common metastatic tumors to the brain are
lung
renal
melanoma
Melanocytes have what embryologic origin
Melanocytes
Bullous pemphigoid
autoantibodies against hemidesmosomes along basement membrane of dermal-epidermal junction
-entire epidermis separates from dermis, forming blister
Immunofluresence for Bullouspemphigoid
IgG and/or C3 deposits in linear pattern
Bacillary angiomatosis found in what infection
Bartonella Henselae
Describe bacillary angiomatosis
Benign capillary skin papules
Niacin is derived from what
Tryptophan!!!!!
Niacin is essential for what biochemical molecules
NAD and NADP
Niacin deficiency can cause
Pellagra: diarrhea, Dementia
Arginine is precursor for what
- nitric oxide
- urea
- ornithine
- agmatine
Carotene is a precursor for
vitamin A
Cholesterol is a precursor for
steroid hormone
Orotic acid is a precursor for
pyrimidine
PHenylalaine is precrusor for
tyrosine
At what sites does splicing occur
GU at 5’ splice stie
AG at 3’ splice site
Phemphigus vulgaris
autoimmune against desmosomal proteins
Presentation of phempigus vulgarism
- painful flaccid bullae
- spread laterally with pressure
- new blisters may form with gentle rubbing
What can cause pyrimidine dimers in DNA
Ultraviolet light exposure
Screening for RPR or VDRL, and confirmatory test FTA-ABS is for what
Treponema pallidum
