Chapter 15: Adaptive Immune Response - T Cell response

Question 1

What is the function of cytotoxic T cells? (2)

Answer 1

• destroys abnormal cells
• recognizes antigens presented along with MHC I
  ex. infected cells, cancer cells

Question 2

Which cells is MHC I found in?

Answer 2

ALL (in lecture)

Question 3

How are T cells activated? (3)

Answer 3

1. a dendritic cell engulfs foreign antigen
2. presents antigen to specific Tc cell
3. Tc is activated to undergo clonal explansion

Question 4

What does T cell activation produce? (2)

Answer 4

• memory T cells
• cytotoxic T lymphocytes (CTLS)

Question 5

What happens when cytotoxic T lymphocytes are activated? (2)

Answer 5

• any body cell can serve as APC ( bc all cells carry MHC I)
• endogenous antigen presented on cell surface, along with MHC I

Question 6

When a CTL attaches to an abnormal cell, what does it release? (2)

Answer 6

1. perforins
2. granzymes

Question 7

What are perforins?

Answer 7

• enzymes that poke holes in the abnormal cell’s membrane

Question 8

What are granzymes?

Answer 8

• enzymes that induce apoptosis