Chapter 14: The innate Immune Response - Inflammatory Response + IFN Flashcards
1
Q
What occurs in an inflammatory response in response to tissue damage?
A
- blood vessels dilate
- fluid leaks
- leukocytes migrate into tissues
2
Q
Based on the previous answer on what occurs in an inflammatory response, what does it allow for? (3)
A
- more blood reaches area
- allows phagocytes to enter tissues - increased phagocytosis
- brings platelets to form blood clots and nutrients for faster repair
2
Q
Based on the previous answer on what occurs in an inflammatory response, what does it allow for? (3)
A
- more blood reaches area
- allows phagocytes to enter tissues - increased phagocytosis
- brings platelets to form blood clots and nutrients for faster repair
3
Q
What are signs and symptoms of imflammation? (4)
A
- pain, swelling
- Heat, redness
- edema
- loss of function
4
Q
What is a fever triggered by? (3)
A
- toxins
- LPS (lipopolysaccharides) (gram -)
- chemicals produced by the immune system
5
Q
What can fever result in? (2)
A
- rapid muscle contraction (shivering)
- increased temperature
6
Q
What are the benefits of fever? (4)
A
- faster phagocytosis
- slows growth of heat limited microbes (e.coli)
- faster metabolism for healing
- up to a certain temperature, fever is a denfense against diseases
7
Q
How is E.coli an example of how fever can slow the growth of heat limited microbes?
A
- E. coli prefers to grow at 37C but growth slows at 40C
8
Q
What are drawbacks of fever?
A
- uncomfortable
- fever above 43C can cause death
9
Q
What are anti-viral interferons (IFNs)?
A
- produced when cells detect viral DNA
- released by infected cells to warn neighbouring cells
10
Q
How do anti-viral interferons work? (3)
A
- induces neighboring cells to enter into an antiviral state
- does not help cells that are already infected
- neighbouring cells undergo apoptosis if infected
11
Q
In lecture, what is rotavirus?
A
- double stranded RNA virus
- goes into your system and your body produces IFN
