Chapter 15: Adaptive Immune Response - Five Classes of Antibodies Flashcards
1
Q
What are five classes of antibodies?
A
- Immunogoblin G
- immunogoblin M
- Immunogoblin A
- Immunigoblin D
- immunogoblin E
2
Q
What is the most abundant antibody?
A
IgG
3
Q
What is the function of IgG? (2)
A
- binds to antigens very strongly
- can cross placenta (only one) to confer passive immunity to fetus
4
Q
Where is IgG found?
A
- blood, but can enter tissues in regions of inflammation
5
Q
What is the half life of IgG?
A
21 days (80-85%)
6
Q
What is the first Ab produced upon infection?
A
IgM
7
Q
Where is IgM found? (2)
A
- stays in blood (does not move freely like IgG)
- often attached to surface of B cells
8
Q
What does IgM consist of?
A
- 5 units of Ab
- aka a pentameter
9
Q
What is the purpose of IgM?
A
- very good at cross-linking antigens
10
Q
What is the half life of IgM?
A
10 days
11
Q
What does IgA consist of?
A
- 2 units of Ab
- dimer
12
Q
Where is IgA found?
A
- found in body secretions
- saliva, mucous, tears, milk
13
Q
What is the function of IgA? (2)
A
- protect mucosal surfaces
- protect GI tract of newborns
note that IgA is also called secretory Ab
14
Q
What is the half-life of IgA?
A
6 days
15
Q
What is IgD? aka function, location (3)
A
- function is unknown
- found in serum
- backup in case IgG is non-functional or not made
know that people without IgG have a short life
