TM 6 (Transfusion complications)

Question 1

RBC bacterial contaminants

Answer 1

Yersinia
Citrobacter
E. coli
Pseudomonas

Question 2

Platelet bacterial contaminants

Answer 2

G+ cocci

Question 3

Type of transplant with lease risk for GVHD

Answer 3

cord blood

Question 4

Major ABO incomplatibility in SCT

Answer 4

new red cell antigen (A to an O person)

Question 5

Minor ABO incompatibility in SCT

Answer 5

New Ab (O to A person)

Question 6

In major mismatch, transfuse

Answer 6

recipeint RBC type

donor FFP/plt type

Question 7

In minor mismatch, transfuse

Answer 7

donor RBC type

recipient FFP/plt type

Question 8

In major and minor mismatch, transfuse

Answer 8

O RBCs

AB plasma

Question 9

3 massive transfusion definitions

Answer 9

1. 1 blood volume in 24hr
2. 10-20 units in 24hr
3. 50% blood volume in 3 hr

Question 10

Things that decrease in stored blood

Answer 10

2,3-DPG
pH
ATP
Coags

Question 11

Things that increase in stored blood

Answer 11

K+

free HGB

Question 12

oxygen affinity curve in ____ shifted in stored blood

Answer 12

left

increased O2 affinity

Question 13

Factors ____ and ____ degrade most quickly in stored blood

Answer 13

V and VIII

Question 14

Penicillin +DAT mechanism

Answer 14

Drug absorption (hapten)

Question 15

Cephalothin +DAT mechanism

Answer 15

non-immune protein adsorption (non-specific coating)

Question 16

Drugs with immune complex mechanism for +DAT

Answer 16

Quinidine
Phenacetin
Cephaolsporins
(+ for C3d only)

Question 17

Drugs causing true warm autoimmune hemolytic anemia

Answer 17

aldomet

procainamide

Question 18

T1/2 of Factor 8

Answer 18

12 hr

Question 19

T1/2 of Factor 9

Answer 19

8 hr