Hematology 4 Flashcards
1
Q
hereditary spherocytosis cause
A
Ankyrin
2
Q
Hereditary elliptocytosis cause
A
Spectrin A
3
Q
Southeast Asian ovalocytosis cuase
A
Band 3
4
Q
Beta globin chain located on Ch
A
11
5
Q
Hb Lepore
A
delta-beta fusion
6
Q
MCV/RBC ratio in thalassemia
A
<13
7
Q
HbConstant Spring
A
extra-long alpha chain (looks like alpha thal)
8
Q
HbH disease
A
deletion of 3 alpha genes, Beta tetramers
9
Q
%HbS in SA
A
35-45%
10
Q
%HbS in S-alpha-thal
A
23-35%
11
Q
% HbS in S-Beta-thal
A
> 80%
12
Q
Most specific (1) and most sensitive (1) antibodies in pernicous anemia
A
specific = anti-intrinsic factor sensitive = anti-parietal cell
13
Q
homocysteine and methylmalonic acid both increased in
A
B12 deficiency
14
Q
Defect in Pelger Huet
A
LaminB mutation
15
Q
Chronic granulomatous disease infections
A
catalast + bacteria, fungal, S aureus, salmonella, serratia, aspergillus, nocardia
