Chemistry 8 (Pregnancy) Flashcards

1
Q

bilirubin peak absorbance

A

450nm

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2
Q

liley chart

A

deltaOD450 by gestational age

if in zone 3 or increasing in zone 2; then deliver if >36wk or transfuse if less

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3
Q

alpha subunit of hCG same as

A

TSh, FSH, LH

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4
Q

hCG first detectable at _____day, _____mIU/mL

A

6-8d

10-50mIU/mL

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5
Q

hCG level doubles every ____ days until level of ____ around ____

A

2days
1200
10weeks

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6
Q

between ____ and ____ level, hCG doubles every ____days

A

1200-6000

3days

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7
Q

hCG doubles every ____ days above____ until a peak of ____ around ____

A

4days
6000
100,000
end of first trimester

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8
Q

increased hCG in

A
multiples
polyhydraminios
eclampsia
HDFN
GTF
Tri21
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9
Q

abnormal pregnancy if hCH does not rise at least ___ in ___ or if it falls in that time

A

66% in 48hr

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10
Q

with transabdominal US, gestational sac detectable if hCG

A

6000

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11
Q

with transvaginal US, gestational sac detectable if hGC

A

1400

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12
Q

serum progesterone ____ assures IUP

levels ____ predictive of abnormal

A

> 25

<5

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13
Q

risk for malignant dz in partial and complete mole

A

<5%

20%

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14
Q

follow-up of mole

A

monitor weekly until undetactable x3wk, then monthly x1yr

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15
Q

Triple screen

A

hCG, AFP and estriol at 18wk

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16
Q

Quad test

A

triple screen plus dimeric inhibin A (DIA)

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17
Q

Advantage of DIA in quad test

A

stable during 2nd trimester

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18
Q

in diabeteic mothers, ___ and ___ are ___

A

uE and hCG mildly decreased

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19
Q

in smokers, ___ is increased and ___ is decreased

A

AFP increased

uE and hCG decreased

20
Q

pattern in tri18

A

decreased AFP, hCG and uE

21
Q

pattern in NTD

A

increased AFP
normal hCG
decreased uE

22
Q

pattern in Tri21

A

decreased AFP and uE

increased hCG and DIA

23
Q

increased AFP in

A
NTD
ophalocele
renal abnormalities
sacrococcygeal teratoma
cystic hygroma
hydrops
Turner
bowel obstruction
Twins
fetal demise
fetal-maternal hemorrhage
24
Q

uE is good indicator of

A

Tri18
Smith-Lemli-Opitz
hereditary deficiency of steroid sulfatase

25
Q

DIA increased in

A

Trisomy 21

26
Q

___ of fetal fibronectin has high ____ for preterm birth

A

absence

NPV

27
Q

majority of lecithin produced by type II pneumocytes is

A

DSPC

28
Q

test for getal lung maturity best to use if specimen is suboptimal

A

PG test

29
Q

L/S ratio considered mature at

A

2:1

30
Q

problems in L/S ratio

A

not reliable in DM
meconium causes false low
blood makes it be around 1.5

31
Q

which tests not interfered by blood or meconium

A

PG and DSPC

32
Q

foam stability index of ___ is considered mature

A

2:1

33
Q

lamellar body number density of ____ is predictive fo maturity

A

> 50,000

34
Q

fluorescence polarization value of ____ is considered mature

A

290 immature)

35
Q

influence of blood on fluorescence polarization

A

decreases high values, increases low values

if <230, definitely mature even with blood contam

36
Q

values that increase in pregnancy

A

fatty acids
triglycerides
transport proteins
GFR

37
Q

cause of insulin resistance in preg

A

hPL

38
Q

autoimmune dzs that tend to get better in preg

A

Graves

RA

39
Q

autoimmune dzs exacerbated in preg

A

SLE

40
Q

autoimmine dzs notorious for postpartum exacerbation

A

Graves

MG

41
Q

Mortality in SLE during pregnancy due to

A

pulmonary hemorrhage

stroke

42
Q

congenital heart block

A

assd with anti-SS-A or B in SLE

43
Q

transient hyperthyroidism of hyperemesis gravidarum due to

A

very high hCG

44
Q

labs in intrahepatic cholestasis

A

alk phos inreased 5-10x
increased GGT and 5’-nucleotidase
bile acids increased 10x
increased conjugated bili

45
Q

infections indicated in recurrent preg loss

A

Ureaplasma urealyticum

Chlamydia trachomatis