Chemistry 8 (Pregnancy) Flashcards
bilirubin peak absorbance
450nm
liley chart
deltaOD450 by gestational age
if in zone 3 or increasing in zone 2; then deliver if >36wk or transfuse if less
alpha subunit of hCG same as
TSh, FSH, LH
hCG first detectable at _____day, _____mIU/mL
6-8d
10-50mIU/mL
hCG level doubles every ____ days until level of ____ around ____
2days
1200
10weeks
between ____ and ____ level, hCG doubles every ____days
1200-6000
3days
hCG doubles every ____ days above____ until a peak of ____ around ____
4days
6000
100,000
end of first trimester
increased hCG in
multiples polyhydraminios eclampsia HDFN GTF Tri21
abnormal pregnancy if hCH does not rise at least ___ in ___ or if it falls in that time
66% in 48hr
with transabdominal US, gestational sac detectable if hCG
6000
with transvaginal US, gestational sac detectable if hGC
1400
serum progesterone ____ assures IUP
levels ____ predictive of abnormal
> 25
<5
risk for malignant dz in partial and complete mole
<5%
20%
follow-up of mole
monitor weekly until undetactable x3wk, then monthly x1yr
Triple screen
hCG, AFP and estriol at 18wk
Quad test
triple screen plus dimeric inhibin A (DIA)
Advantage of DIA in quad test
stable during 2nd trimester
in diabeteic mothers, ___ and ___ are ___
uE and hCG mildly decreased
in smokers, ___ is increased and ___ is decreased
AFP increased
uE and hCG decreased
pattern in tri18
decreased AFP, hCG and uE
pattern in NTD
increased AFP
normal hCG
decreased uE
pattern in Tri21
decreased AFP and uE
increased hCG and DIA
increased AFP in
NTD ophalocele renal abnormalities sacrococcygeal teratoma cystic hygroma hydrops Turner bowel obstruction Twins fetal demise fetal-maternal hemorrhage
uE is good indicator of
Tri18
Smith-Lemli-Opitz
hereditary deficiency of steroid sulfatase
DIA increased in
Trisomy 21
___ of fetal fibronectin has high ____ for preterm birth
absence
NPV
majority of lecithin produced by type II pneumocytes is
DSPC
test for getal lung maturity best to use if specimen is suboptimal
PG test
L/S ratio considered mature at
2:1
problems in L/S ratio
not reliable in DM
meconium causes false low
blood makes it be around 1.5
which tests not interfered by blood or meconium
PG and DSPC
foam stability index of ___ is considered mature
2:1
lamellar body number density of ____ is predictive fo maturity
> 50,000
fluorescence polarization value of ____ is considered mature
290 immature)
influence of blood on fluorescence polarization
decreases high values, increases low values
if <230, definitely mature even with blood contam
values that increase in pregnancy
fatty acids
triglycerides
transport proteins
GFR
cause of insulin resistance in preg
hPL
autoimmune dzs that tend to get better in preg
Graves
RA
autoimmune dzs exacerbated in preg
SLE
autoimmine dzs notorious for postpartum exacerbation
Graves
MG
Mortality in SLE during pregnancy due to
pulmonary hemorrhage
stroke
congenital heart block
assd with anti-SS-A or B in SLE
transient hyperthyroidism of hyperemesis gravidarum due to
very high hCG
labs in intrahepatic cholestasis
alk phos inreased 5-10x
increased GGT and 5’-nucleotidase
bile acids increased 10x
increased conjugated bili
infections indicated in recurrent preg loss
Ureaplasma urealyticum
Chlamydia trachomatis
