Microbiology 3 (virology)

Question 1

Hepadnavirus

Answer 1

Hep B (enveloped DNA)

Question 2

Hep B ____ indicates active disease

Answer 2

surface antigen

HBsAg

Question 3

Hep B ____ indicates active viral replication

Answer 3

e antigen

HBeAg

Question 4

Hep B _____ indicates resistance to infection

Answer 4

Antibody against surface antigen

HBsAb (Anti-HBs)

Question 5

Marker in Hep B that occurs before clinical symptoms

Answer 5

HBsAg (and DNA)

Question 6

what is “window” period in HepB

Answer 6

period between disappearance of HBsAg and appearance of Anti-HBs

Question 7

Resolved HBV

Answer 7

Anti-HBc, Anti-HBs

Question 8

Immunized against HBV

Answer 8

Anti-HBs

Question 9

Chronic hepatitis B definition

Answer 9

HBsAg >6mo (5% of adults

Question 10

who has highest rate of conversion to chronic HepB

Answer 10

neonates infected transplacentally (90%)

Question 11

Chronic HBs antigenemia assd with

Answer 11

Polyarteritis nodosum

Question 12

titer considered “replicative” in HepB

Answer 12

> 10^5/ml HBV DNA

Question 13

HCV

Answer 13

Flavivirus, enveloped RNA

Question 14

extrahepatic manifestations of HCV

Answer 14

cryoglobulinemia, membranous GN, aplastic anemia

Question 15

sustained virologic response

Answer 15

undetectable (<50IU/mL) HCV RNA 6 months after treatment

Question 16

HCV genotypes with high and low rates of response to treatment

Answer 16

high response: 2&3

low response: 1

Question 17

HAV

Answer 17

picornavirus, non-enveloped RNA

Question 18

other viruses that cause hepatitis

Answer 18

EBV, CMV, HSV, yellow fever

Question 19

orthomyxoviruses

Answer 19

Influenza A&B

Question 20

treatment for influenza A

Answer 20

Amantadine

Question 21

“hemagglutinating viruses”

Answer 21

influenza A&B, parainfluenza

Question 22

calf myositis and ocular pain

Answer 22

influenza B

Question 23

neuraminidase inhibitors include

Answer 23

oseltamivir, zanamivir

Question 24

cause of respiratory bronchiolitis in children <2

Answer 24

parainfluenza 3

Question 25

Cause of croup

Answer 25

parainflenza 1&2, RSV

Question 26

complications of measles

Answer 26

otitis media, myocarditis, SSPE

Question 27

this virus may cause CSF pleocytosis and meningoencephalitis

Answer 27

Mumps

Question 28

Enteroviridae

Answer 28

(in picornaviridae family)

polio, coxsackie, echo, entero

Question 29

most common cause of viral meningitis

Answer 29

enterovirus

Question 30

cause of herpangina and hand, foot, and mouth dz

Answer 30

Coxsackie A

Question 31

Picornaviruses

Answer 31

enteroviridae
rhinovirus
HepA

Question 32

“arboviruses”

Answer 32

Bunyaviridae, Togaviridae, Reoviridae, Rhabdoviridae

Question 33

Coxsackie B causes

Answer 33

epidemic pleurodynia, myocarditis, pericarditis

Question 34

Bunyavirsuses

Answer 34

Hantavirus, hemorrhagic fever viruses

Question 35

Dengue virus

Answer 35

a flavivirus

Question 36

Flaviviruses

Answer 36

yellow fever, west nile, dengue, hep C

Question 37

Togaviruses

Answer 37

Eastern and Western Equine encephalitis, Rubella

Question 38

Midzonal liver necrosis

Answer 38

yellow fever

Question 39

HTLV1 causes

Answer 39

adult Tcell leukemia/lymphoma, tropic spastic paraparesis

Question 40

earlier HIV ELISAs were not as sensitive for

Answer 40

HIV2, HIV1 type O

Question 41

Western blot HIV + if

Answer 41

2 of: p24, gp41, gp120/160

Question 42

False + western blot for HIV in

Answer 42

hyperbilirubinemia, hypergammaglobulinemia, auto-Abs, HLA Abs

Question 43

recommended test for HIV in neonates

Answer 43

PCR for HIV Proviral DNA