Microbiology 3 (virology) Flashcards
Hepadnavirus
Hep B (enveloped DNA)
Hep B ____ indicates active disease
surface antigen
HBsAg
Hep B ____ indicates active viral replication
e antigen
HBeAg
Hep B _____ indicates resistance to infection
Antibody against surface antigen
HBsAb (Anti-HBs)
Marker in Hep B that occurs before clinical symptoms
HBsAg (and DNA)
what is “window” period in HepB
period between disappearance of HBsAg and appearance of Anti-HBs
Resolved HBV
Anti-HBc, Anti-HBs
Immunized against HBV
Anti-HBs
Chronic hepatitis B definition
HBsAg >6mo (5% of adults
who has highest rate of conversion to chronic HepB
neonates infected transplacentally (90%)
Chronic HBs antigenemia assd with
Polyarteritis nodosum
titer considered “replicative” in HepB
> 10^5/ml HBV DNA
HCV
Flavivirus, enveloped RNA
extrahepatic manifestations of HCV
cryoglobulinemia, membranous GN, aplastic anemia
sustained virologic response
undetectable (<50IU/mL) HCV RNA 6 months after treatment
HCV genotypes with high and low rates of response to treatment
high response: 2&3
low response: 1
HAV
picornavirus, non-enveloped RNA
other viruses that cause hepatitis
EBV, CMV, HSV, yellow fever
orthomyxoviruses
Influenza A&B
treatment for influenza A
Amantadine
“hemagglutinating viruses”
influenza A&B, parainfluenza
calf myositis and ocular pain
influenza B
neuraminidase inhibitors include
oseltamivir, zanamivir
cause of respiratory bronchiolitis in children <2
parainfluenza 3
Cause of croup
parainflenza 1&2, RSV
complications of measles
otitis media, myocarditis, SSPE
this virus may cause CSF pleocytosis and meningoencephalitis
Mumps
Enteroviridae
(in picornaviridae family)
polio, coxsackie, echo, entero
most common cause of viral meningitis
enterovirus
cause of herpangina and hand, foot, and mouth dz
Coxsackie A
Picornaviruses
enteroviridae
rhinovirus
HepA
“arboviruses”
Bunyaviridae, Togaviridae, Reoviridae, Rhabdoviridae
Coxsackie B causes
epidemic pleurodynia, myocarditis, pericarditis
Bunyavirsuses
Hantavirus, hemorrhagic fever viruses
Dengue virus
a flavivirus
Flaviviruses
yellow fever, west nile, dengue, hep C
Togaviruses
Eastern and Western Equine encephalitis, Rubella
Midzonal liver necrosis
yellow fever
HTLV1 causes
adult Tcell leukemia/lymphoma, tropic spastic paraparesis
earlier HIV ELISAs were not as sensitive for
HIV2, HIV1 type O
Western blot HIV + if
2 of: p24, gp41, gp120/160
False + western blot for HIV in
hyperbilirubinemia, hypergammaglobulinemia, auto-Abs, HLA Abs
recommended test for HIV in neonates
PCR for HIV Proviral DNA
