Chemistry 15 (Endocrine) Flashcards
In hypothyroidism, T3 resin uptake is
low
In hyperthyroidism, T3 resin uptake is
high
rT3 increased in
euthyroid sick syndrome
hyperthyroid pt with normal or low RAIU
struma ovarii or exogenous thyroid hormone
TRH stimulation test in primary hypoparathyroidism
exaggerated TSH response to TRH
most common cause of hypothyroidism
Hashimoto
Refetoff syndrome
rare peripheral resistance to thyroid hormone
Abs in hashimoto
anti-microsomal, anti-thyroglobulin
genes indicated in familial abnormal thyroid development
PA8, TTF
amiodarone and thyroid
causes hypothyroidism in iodine rich areas
causes hyperthyroidism in iodine poor areas
single elevated midnight serum cortisol
suggests Cushings
in normal, dexamethasome will suppress
CRH, ACTH, and cortisol
low dose dexamethasone test shows
hypercorticalism is present
high dose dexamethasone test shows
hypercorticalism is caused by pituitary adenoma or tumor
metyrapone stimulation test is for
determining the cause of decreased fortisol
best screening test for Cushing
11pm salivary cortisol
which pituitary cells produce ACTH
basophilic
primary adrenal hypercorticalism in children
more likely due to a carcinoma than adenoma
Addison dz =
primary adrenal insufficiency
typical lab values in adrenal failure
hypoglycemia
hyponatremia
hyperkalemia
metabolic acidosis
cosyntropin test
lack of increase in serum cortisol confirms primary adrenal insuffiency
Conn syndrome
hyperaldosteronism
secondary hyperaldosteronism seen in
hyper-renin states (renal artery stenosis, juxtaglonerular cell tumor)
plasma renin activity measures
conversion of angiotensin I to angiotensin II
Renin in primary hyperaldosteonism
low
hyperaldosteronism cuases
hypertension hypervolemia hypernatremia hypokalemia metabolic alkalosis
increased ____ seen in 21-hydroxylase def
17-hydroxyprogesterone
serum K and Na in 21-hydroxylase def
increased K
decreased Na
increased ____ see in 11-hydroxylase def
11-deoxycortisol
what is seen in 11-hydroxylase def but not 21-hydroxylase def
Hypertension
in borderline cases of CAH, ___ test can be used
corticotrophin stimulation test
