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Clinical Pathology > Heme Path 3 > Flashcards

Heme Path 3 Flashcards

1
Q

Clusterin

A

golgi pattern in anaplastic large cell lymphoma

also + in Hodgkin lymphoma

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2
Q

EMA + in (4)

A

PCs
anaplastic large cell lymphoma
NLPHL
TCRBCL

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3
Q

Fascin+ (2)

A

RS cells

dendritic reticulum cells

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4
Q

HLA-DR notibly negative in

A

APL

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5
Q

IgH located on

A

Chromosome 14

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6
Q

Kappa light chain location

A

Chromosome 2

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7
Q

Lambda light chain location

A

Chromosome 22

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8
Q

TCR location

A

Chromosome 7

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9
Q

Three translocations of Burkitt

A

t(8;14)
t(2;8)
t(8;22)
all with Myc

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10
Q

Oct2 and BOB1 consistently + in

A

NLPHL

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11
Q

mantle translocation

A

t(11;14) IgH-CyclinD1

Also Trisomy 12

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12
Q

t(11;14)

A

Mantle

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13
Q

FL translocation

A

t(14;18)

IgH-BCL2

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14
Q

t(14;18)

A

FL

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15
Q

MALT/extranodal marginal genetics

A

Trisomy 3

t(11;18)

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16
Q

Assd with Trisomy 3

A

MALT

17
Q

Assd with Trisomy 12 (2)

A

Atypical CLL/SLL

Mantle

18
Q

Assd with Inv14

A

Tcell Prolymphocytic leukemia

19
Q

t(2;5)

A

anaplastic large cell lymphoma

20
Q

Anaplastic large cell translocation

A

t(2;5)

21
Q

Assd with hemophagocytic syndrome (3)

A

Anaplastic large cell lymphoma
Angioimmunoblastic lymphoma
Gamma-Delta Tcell lymphoma

22
Q

Nodular BM infiltrates that look like CLL see in what non-neoplastic condition

A

HCV

23
Q

Conditions with increased polyclonal CD5+ B cells (3)

A

RA
HCV
post-BMT

24
Q

most common chromosomal abnormality in CLL

A

del13q (good prognosis)

25
Q

CLL transforms to

A

CLL/PLL when prolymphs 11-55%

large b cell lymphoma (Richter)

26
Q

Blastic mantle cell phenotype

A

CD99+, Tdt+, cyclinD1-, CD5-

27
Q

Mantle cell lymphoma is more likely to be ___ restricted

A

lambda

28
Q

most common additional anomaly in Mantle

A

chromosome 13

29
Q

% of marginal zone lymphomas with monoclonal gammopathy

A

30-50%

30
Q

monocytopenia is a clue to

A

Hairy cell leukemia

31
Q

malignancy showing infiltration of spleen red pulp wiht blood lakes

A

hairy cell

32
Q

malignancy with ribosome-lamellar complexes on EM

A

Hairy cell

Clinical Pathology (59 decks)

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