Heme Path 3

Question 1

Clusterin

Answer 1

golgi pattern in anaplastic large cell lymphoma

also + in Hodgkin lymphoma

Question 2

EMA + in (4)

Answer 2

PCs
anaplastic large cell lymphoma
NLPHL
TCRBCL

Question 3

Fascin+ (2)

Answer 3

RS cells

dendritic reticulum cells

Question 4

HLA-DR notibly negative in

Answer 4

APL

Question 5

IgH located on

Answer 5

Chromosome 14

Question 6

Kappa light chain location

Answer 6

Chromosome 2

Question 7

Lambda light chain location

Answer 7

Chromosome 22

Question 8

TCR location

Answer 8

Chromosome 7

Question 9

Three translocations of Burkitt

Answer 9

t(8;14)
t(2;8)
t(8;22)
all with Myc

Question 10

Oct2 and BOB1 consistently + in

Answer 10

NLPHL

Question 11

mantle translocation

Answer 11

t(11;14) IgH-CyclinD1

Also Trisomy 12

Question 12

t(11;14)

Answer 12

Mantle

Question 13

FL translocation

Answer 13

t(14;18)

IgH-BCL2

Question 14

t(14;18)

Answer 14

FL

Question 15

MALT/extranodal marginal genetics

Answer 15

Trisomy 3

t(11;18)

Question 16

Assd with Trisomy 3

Answer 16

MALT

Question 17

Assd with Trisomy 12 (2)

Answer 17

Atypical CLL/SLL

Mantle

Question 18

Assd with Inv14

Answer 18

Tcell Prolymphocytic leukemia

Question 19

t(2;5)

Answer 19

anaplastic large cell lymphoma

Question 20

Anaplastic large cell translocation

Answer 20

t(2;5)

Question 21

Assd with hemophagocytic syndrome (3)

Answer 21

Anaplastic large cell lymphoma
Angioimmunoblastic lymphoma
Gamma-Delta Tcell lymphoma

Question 22

Nodular BM infiltrates that look like CLL see in what non-neoplastic condition

Answer 22

HCV

Question 23

Conditions with increased polyclonal CD5+ B cells (3)

Answer 23

RA
HCV
post-BMT

Question 24

most common chromosomal abnormality in CLL

Answer 24

del13q (good prognosis)

Question 25

CLL transforms to

Answer 25

CLL/PLL when prolymphs 11-55% | large b cell lymphoma (Richter)

Question 26

Blastic mantle cell phenotype

Answer 26

CD99+, Tdt+, cyclinD1-, CD5-

Question 27

Mantle cell lymphoma is more likely to be ___ restricted

Answer 27

lambda

Question 28

most common additional anomaly in Mantle

Answer 28

chromosome 13

Question 29

% of marginal zone lymphomas with monoclonal gammopathy

Answer 29

30-50%

Question 30

monocytopenia is a clue to

Answer 30

Hairy cell leukemia

Question 31

malignancy showing infiltration of spleen red pulp wiht blood lakes

Answer 31

hairy cell

Question 32

malignancy with ribosome-lamellar complexes on EM

Answer 32

Hairy cell