Chemistry 3 (Pancreatic and Cardiac) Flashcards
wheat germ lectin (triticum vulgaris) inhibits what type of amylase
salivary
Fractional excretion equation
(UrineX x Pcreat)/(PlasmaX x Ucreat)
cause of acute pancreatitis without increase amylase
hypertriglyceridemia
non-pancreatic causes of hyperamylasemia
DKA PUD cholecystitis ectobic preg/salpingitis bowel ischemia/obstruction renal insufficiency macroamylasemia
Ranson criteria at admission
Age>55 WBC>16 Glucose>198 AST>250 LDH>350
Ranson criteria at 48hr
Urea>1.8, Ca4, fluid sequestration >6L, Hct drop >10
what has specificity >95% for gallstone pancreatitis
ALT>150
what is suggestive of EtOH pancreatitis
Lipase/Amylase >5
causes of familial pancreatitis
Cationic trypsinogen (PRSS1) Pancreatic secretory trypsin inhibitor (PST1) CFTR
D-xylose test measures
small bowel mucosal absorptive capacity
Pancreatic lesions with increased amylase
Pseudocyst, IPMN
Pancreatic lesions with increased CEA
MCN, IPMN
CK enzyme types
BB (CK1), MB (CK2), MM (CK3)
location of CK-BB
brain > stomach, bladder, prostate
also migrates the fastest
most widely distributed CK
CK-BB
slowest migrating CK
CK-MM
Skeletal muscle is ___% CK-MM
99%
Cardiac muscle is ___% CK-MM
70%
What percent of cardiac muscle is CK-MB
30%
Macro-CK is ____ and is found in ____
CK-Ig complexes
healthy elderly women
type of CK assd with poor prognosis
Mitochondrial (seen in advanced malignancies)
most sensitive marker of cardiac damage
myoglobin (also least specific)
most specific myocardial marker
cTnI
earliest cardiac marker
myoglobin
ischemia-modified albumin returns to baseline in
6hr
natriuretic peptide causes
vasodilation and natriuresis
stable fragment of BNP that is measured
N-terminal pro-BNP
cTnI remains elevated
2wks
time course of CK-MB
detect at 3-6hr
peaks at 20-24 hr
baseline at 72 hr
marker with highest NPV at 2hr following onset
myoglobin
