Heme Path 5 Flashcards
Lab abnormality in Adult Tcell leukemia/lymphoma
hypercalcemia caused by OAF
lymphoma assd with Coombs+ autoimmune hemolytic anemia, rash and polyclonal hypergammaglobulinemia
angioimmunoplastic
phenotype of anaplastic large cell lymphoma
CD30, ALK, Clusterin, EMA, CD45, (at least 1 Tcell marker, unless null phenotype)
ALK expression corelates with what translocation
t(2;5)
Clusterin
Golgi staining in anaplastic large cell lymphoma
Phenotype of angioimmunoblastic
CD3, CD10, EBER, CXCL13, PD1
clinical of hepatosplenic gamma-delta
young men, B-symphoms, red pulp expansion
chromosomal abnormality in hepatosplenic gamma-delta
isochromosome 7q
antigen classically seen in blastic NK cell lymphoma
CD123
“lacunar cell”
nodular sclerosis HL
morphology of 5q- syndrome
hypolobated megakaryocytes
translocation in CMML with eosinophilia
t(5;12)
JMML assd with what syndrome
NF1
increased B12 assd with
CML
chromosome abnormality that may herald accelerated phase of CML
17p
Gaisbock syndroem
reactive polycythemia in stress of dehydration
most common cuase of Budd-Chiari syndrome
PV
mutation in PV
Jak2 (Val 617 Phe)
histology of ET
large, hyperlobated megakaryocytes
AML with t(8;21) morphology
pseudo Chediak-Higashi cells
AML wtih inv(6) morphology
abnormal eos
“other” APL translocations
t(5:17), t(11;17)
AML with 11q abnormalityies seen in
young people treated with topoisomerase II inhibitors
amnt of dysplasia required for AML with multilineage dysplasia
> 50% in 2 lines
Acute megakaryoblastic leukemia assd conditions (2)
Down syndrome
Mediastinal germ cell tumors
lymphomatous polyposis
polypoid mantle cell lymphpma in ileocecal region
Kostman syndrome
a congenital neutropenia
WIscott-ALdrich syndrome
thrombocytopenia, immune deficiency, eczema
WHIM syndrome
Warts
Hypogammaglobulinemia
Infections
Myelokathexis
