Heme Path 5

Question 1

Lab abnormality in Adult Tcell leukemia/lymphoma

Answer 1

hypercalcemia caused by OAF

Question 2

lymphoma assd with Coombs+ autoimmune hemolytic anemia, rash and polyclonal hypergammaglobulinemia

Answer 2

angioimmunoplastic

Question 3

phenotype of anaplastic large cell lymphoma

Answer 3

CD30, ALK, Clusterin, EMA, CD45, (at least 1 Tcell marker, unless null phenotype)

Question 4

ALK expression corelates with what translocation

Answer 4

t(2;5)

Question 5

Clusterin

Answer 5

Golgi staining in anaplastic large cell lymphoma

Question 6

Phenotype of angioimmunoblastic

Answer 6

CD3, CD10, EBER, CXCL13, PD1

Question 7

clinical of hepatosplenic gamma-delta

Answer 7

young men, B-symphoms, red pulp expansion

Question 8

chromosomal abnormality in hepatosplenic gamma-delta

Answer 8

isochromosome 7q

Question 9

antigen classically seen in blastic NK cell lymphoma

Answer 9

CD123

Question 10

“lacunar cell”

Answer 10

nodular sclerosis HL

Question 11

morphology of 5q- syndrome

Answer 11

hypolobated megakaryocytes

Question 12

translocation in CMML with eosinophilia

Answer 12

t(5;12)

Question 13

JMML assd with what syndrome

Answer 13

NF1

Question 14

increased B12 assd with

Answer 14

CML

Question 15

chromosome abnormality that may herald accelerated phase of CML

Answer 15

17p

Question 16

Gaisbock syndroem

Answer 16

reactive polycythemia in stress of dehydration

Question 17

most common cuase of Budd-Chiari syndrome

Answer 17

PV

Question 18

mutation in PV

Answer 18

Jak2 (Val 617 Phe)

Question 19

histology of ET

Answer 19

large, hyperlobated megakaryocytes

Question 20

AML with t(8;21) morphology

Answer 20

pseudo Chediak-Higashi cells

Question 21

AML wtih inv(6) morphology

Answer 21

abnormal eos

Question 22

“other” APL translocations

Answer 22

t(5:17), t(11;17)

Question 23

AML with 11q abnormalityies seen in

Answer 23

young people treated with topoisomerase II inhibitors

Question 24

amnt of dysplasia required for AML with multilineage dysplasia

Answer 24

> 50% in 2 lines

Question 25

Acute megakaryoblastic leukemia assd conditions (2)

Answer 25

Down syndrome

Mediastinal germ cell tumors

Question 26

lymphomatous polyposis

Answer 26

polypoid mantle cell lymphpma in ileocecal region

Question 27

Kostman syndrome

Answer 27

a congenital neutropenia

Question 28

WIscott-ALdrich syndrome

Answer 28

thrombocytopenia, immune deficiency, eczema

Question 29

WHIM syndrome

Answer 29

Warts
Hypogammaglobulinemia
Infections
Myelokathexis