Coag 2

Question 1

GP Ib/V/IX

Answer 1

how platelets attach to vWF

Question 2

substances in delta granules

Answer 2

ADP
ATP
serotonin
Ca

Question 3

GP IIb/IIIa

Answer 3

binds fibrinogen

Question 4

GP IIb/IIIa inhibitors

Answer 4

abciximab
integrilin
aggrastat

Question 5

diseases of primary hemostasis

Answer 5

Bernard-Soulier
Glanzmann
vWD

Question 6

hematomas and hemarthroses due to defects in

Answer 6

secondary hemostasis

Question 7

vWF made in

Answer 7

endothelial cells

megakaryocytes

Question 8

negatively charged glass activaes

Answer 8

intrinsic pathway

Question 9

tissue factor activates

Answer 9

extrinsic pathway

Question 10

defects of pre-kalllikrein and kallikrein

Answer 10

increased PTT

no bleeding problem

Question 11

factor 7 activates

Answer 11

10 and 9

Question 12

tissue factor pathway inhibitor binds

Answer 12

factor 10a

Question 13

thrombin converts

Answer 13

fibrinogen to fibrin

Question 14

thrombin activates factors

Answer 14

5, 8, 11, 13

fibrinogen to fibrin

Question 15

_______ cross-links fibrin

Answer 15

13

Question 16

_____dissolves fibrin

Answer 16

plasmin

Question 17

Plasminogen converted into plasmin by

Answer 17

tissue plasminogen activator

urokinase/streptokinase

Question 18

Inhibitors of fibrinolysis

Answer 18

TPA inhibitor
alpha-2-antiplasmin
TAFI (thrombin activatable fibrinolysis inhibitor)

Question 19

Protein C activated by

Answer 19

Thrombomodulin boud to thrombin

Question 20

Protein C and Protein S

Answer 20

inhibit factors 5 and 8

Question 21

antithrombin binds to ___ and inhibits___

Answer 21

binds to heparin

inhibits factors 2(thrombin),9,10,11,12

Question 22

PTT measures

Answer 22

all factors except 7 and 13

Question 23

INR calculation

Answer 23

(paient PT/normal mean PT)^ISI

Question 24

Factor 13 deficient labs

Answer 24

normal PT/PTT and platelets

Question 25

increased PT only

Answer 25

Factor 7 deficiency/inhibitor
coumadin
liver dz
dysfibrinoginemia

Question 26

increased PTT only

Answer 26

heparin
vWD
deficiencies of 8, 9, 11
lupus anticoagulant

Question 27

increased PT and PTT

Answer 27

liver dz
vit K def
coumadin or heparin
DIC
dysfibrinogenemia

Question 28

increased PT and PTT with decreased platelets

Answer 28

DIC
liver disease
HIT

Question 29

thrombin time measures

Answer 29

conversion of fibrinogen to fibrin

Question 30

things that increase thrombin time

Answer 30

paraprotein
heparin
dysfibrinogenemia

Question 31

reptilase time measures

Answer 31

fibrinogen to fibrin but insensitive to heparin

Question 32

Increased reptilase time caused by

Answer 32

dysfibrinogenemia

Question 33

time-dependent prolangation of mixing study seen in

Answer 33

factor 8 inhibitor

Question 34

1st phase of platelet agg caused by

Answer 34

ADP release

Question 35

2nd phase of platelet agg caused by

Answer 35

ADP and TXA2

Question 36

biphasic platelet aggs (2)

Answer 36

ADP and epinephrine

Question 37

what would cause loss of 2nd phase of platelet agg with ADP and epi

Answer 37

aspirin

storage pool defect