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Clinical Pathology > Coag 2 > Flashcards

Coag 2 Flashcards

1
Q

GP Ib/V/IX

A

how platelets attach to vWF

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2
Q

substances in delta granules

A

ADP
ATP
serotonin
Ca

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3
Q

GP IIb/IIIa

A

binds fibrinogen

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4
Q

GP IIb/IIIa inhibitors

A

abciximab
integrilin
aggrastat

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5
Q

diseases of primary hemostasis

A

Bernard-Soulier
Glanzmann
vWD

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6
Q

hematomas and hemarthroses due to defects in

A

secondary hemostasis

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7
Q

vWF made in

A

endothelial cells

megakaryocytes

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8
Q

negatively charged glass activaes

A

intrinsic pathway

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9
Q

tissue factor activates

A

extrinsic pathway

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10
Q

defects of pre-kalllikrein and kallikrein

A

increased PTT

no bleeding problem

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11
Q

factor 7 activates

A

10 and 9

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12
Q

tissue factor pathway inhibitor binds

A

factor 10a

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13
Q

thrombin converts

A

fibrinogen to fibrin

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14
Q

thrombin activates factors

A

5, 8, 11, 13

fibrinogen to fibrin

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15
Q

_______ cross-links fibrin

A

13

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16
Q

_____dissolves fibrin

A

plasmin

17
Q

Plasminogen converted into plasmin by

A

tissue plasminogen activator

urokinase/streptokinase

18
Q

Inhibitors of fibrinolysis

A

TPA inhibitor
alpha-2-antiplasmin
TAFI (thrombin activatable fibrinolysis inhibitor)

19
Q

Protein C activated by

A

Thrombomodulin boud to thrombin

20
Q

Protein C and Protein S

A

inhibit factors 5 and 8

21
Q

antithrombin binds to ___ and inhibits___

A

binds to heparin

inhibits factors 2(thrombin),9,10,11,12

22
Q

PTT measures

A

all factors except 7 and 13

23
Q

INR calculation

A

(paient PT/normal mean PT)^ISI

24
Q

Factor 13 deficient labs

A

normal PT/PTT and platelets

25
Q

increased PT only

A

Factor 7 deficiency/inhibitor
coumadin
liver dz
dysfibrinoginemia

26
Q

increased PTT only

A

heparin
vWD
deficiencies of 8, 9, 11
lupus anticoagulant

27
Q

increased PT and PTT

A 
liver dz
vit K def
coumadin or heparin
DIC
dysfibrinogenemia
28
Q

increased PT and PTT with decreased platelets

A

DIC
liver disease
HIT

29
Q

thrombin time measures

A

conversion of fibrinogen to fibrin

30
Q

things that increase thrombin time

A

paraprotein
heparin
dysfibrinogenemia

31
Q

reptilase time measures

A

fibrinogen to fibrin but insensitive to heparin

32
Q

Increased reptilase time caused by

A

dysfibrinogenemia

33
Q

time-dependent prolangation of mixing study seen in

A

factor 8 inhibitor

34
Q

1st phase of platelet agg caused by

A

ADP release

35
Q

2nd phase of platelet agg caused by

A

ADP and TXA2

36
Q

biphasic platelet aggs (2)

A

ADP and epinephrine

37
Q

what would cause loss of 2nd phase of platelet agg with ADP and epi

A

aspirin

storage pool defect

Clinical Pathology (59 decks)

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