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Clinical Pathology > Autoimmunity 2 > Flashcards

Autoimmunity 2 Flashcards

1
Q

pANCA seen in (4)

A

microscopic polyangiitis,
polyarteritis nodosa,
PSC,
UC

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2
Q

ACE increased in (4)

A

sarcoidosis, PBC, Gaucher, leprosy

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3
Q

HLA-DR3 (7)

A

IDDM, SLE, Sjogren, myastenia gravis, DH, celiac, Graves

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4
Q

HLA-DR4 (3)

A

IDDM, RA, pemphigus

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5
Q

HLA-DR2 (3)

A

MS, IDDM, narcolepsy

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6
Q

HLA-B27

A

ankylosing spondylitis

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7
Q

Coxsackie B assd with what autoimmune disorder

A

IDDM

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8
Q

HBV assd with what autoimmune disorder

A

Polyarteritis nodosum

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9
Q

K. pneumonia assd with what autoimmune disorder

A

ankylosing spondylitis

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10
Q

Aldoment assd with

A

warm autoimmune hemolytic anemia

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11
Q

Penicillamine assd with

A

systemic vasculitis

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12
Q

Type I hypersensitivity

A

Immediate, IgE

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13
Q

Type II hypersensitivity

A

AB mediated (goodpasture, MG)

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14
Q

Type III hypersensitivity

A

immune complex (SLE, HSP, post-infectious GN, membranous GN)

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15
Q

Type IV hypersensitivity

A

delayed type, T cells

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16
Q

HLA types assd with celiac dz

A

DQ2, DQ8

17
Q

other dz assd with celiac (3)

A

DM, IgA def, CF

18
Q

serologic markers of celiac (3)

A

anti-gliadin, anti-endomysial, anti-transglutaminase

19
Q

what test correlates well with mucosal recovery in celiac

A

Tranthyretin

20
Q

other conditions assd with autoimmune hepatitis (6)

A

UC, arthritis, ITP, autoimmune hemolytic anemia, thyroiditis, DM

21
Q

PBC is assd with increased

A

Increased IgM

22
Q

Dermatomyositis assd with

A

heliotrope rash, Gottron papules

23
Q

AB assd with poor prognosis in polymyositis

A

ANti-SRP

24
Q

Antibody assd with good prognosis in dermatomyositis

A

Anti-Mi2

25
Q

Ab in myasthemia gravis

A

Anti-AChR

26
Q

Ab assd with refracorty MG in young females with bulbar symptoms

A

ANti-MuSK

27
Q

what can be tested to diagnose anaphylaxis

A

serum tryptase, plasma histamine (only lasts 10 mins), urine histamine (may last 24hr)

28
Q

Total tryptase reflects

A

Mast cell burden

29
Q

Mature tryptase reflects

A

mast cell degranulation

Clinical Pathology (59 decks)

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