Autoimmunity 2 Flashcards
pANCA seen in (4)
microscopic polyangiitis,
polyarteritis nodosa,
PSC,
UC
ACE increased in (4)
sarcoidosis, PBC, Gaucher, leprosy
HLA-DR3 (7)
IDDM, SLE, Sjogren, myastenia gravis, DH, celiac, Graves
HLA-DR4 (3)
IDDM, RA, pemphigus
HLA-DR2 (3)
MS, IDDM, narcolepsy
HLA-B27
ankylosing spondylitis
Coxsackie B assd with what autoimmune disorder
IDDM
HBV assd with what autoimmune disorder
Polyarteritis nodosum
K. pneumonia assd with what autoimmune disorder
ankylosing spondylitis
Aldoment assd with
warm autoimmune hemolytic anemia
Penicillamine assd with
systemic vasculitis
Type I hypersensitivity
Immediate, IgE
Type II hypersensitivity
AB mediated (goodpasture, MG)
Type III hypersensitivity
immune complex (SLE, HSP, post-infectious GN, membranous GN)
Type IV hypersensitivity
delayed type, T cells
HLA types assd with celiac dz
DQ2, DQ8
other dz assd with celiac (3)
DM, IgA def, CF
serologic markers of celiac (3)
anti-gliadin, anti-endomysial, anti-transglutaminase
what test correlates well with mucosal recovery in celiac
Tranthyretin
other conditions assd with autoimmune hepatitis (6)
UC, arthritis, ITP, autoimmune hemolytic anemia, thyroiditis, DM
PBC is assd with increased
Increased IgM
Dermatomyositis assd with
heliotrope rash, Gottron papules
AB assd with poor prognosis in polymyositis
ANti-SRP
Antibody assd with good prognosis in dermatomyositis
Anti-Mi2
Ab in myasthemia gravis
Anti-AChR
Ab assd with refracorty MG in young females with bulbar symptoms
ANti-MuSK
what can be tested to diagnose anaphylaxis
serum tryptase, plasma histamine (only lasts 10 mins), urine histamine (may last 24hr)
Total tryptase reflects
Mast cell burden
Mature tryptase reflects
mast cell degranulation
