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Clinical Pathology > Immunology 3 > Flashcards

Immunology 3 Flashcards

1
Q

Common variable immunodeficiency has decreased

A

IgG, IgM, IgA

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2
Q

clinical presentation of CVID

A

recurrent upper and lower resp infections, bronchiectasis, Giadiasis

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3
Q

Histology in CVID

A

Hypoplastic germinal centers

no plasma cells

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4
Q

clinical of selective IgA deficiency

A

respiratory and GI bacterial infection

autoimmunity

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5
Q

Job syndrome

A

hypergammaglobulin E

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6
Q

clinical of Job syndrome

A

susceptible to Staph, eosinophilia, eczema

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7
Q

DiGeorge genetics

A

del 22q (or del 10p)

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8
Q

Del 22q assd with what conditions

A

DiGeorge,
Velocaridalfacial
Shprintzen syndrome

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9
Q

DiGeorge clinical

A

hypercalcemia
hypoplastic thymus and parathyroids,
typical facies
great vessel anomalies

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10
Q

histology in DiGeorge

A

depleted paracortex, decreased PALS in spleen

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11
Q

SCID genetics

A

50% X-linked, defect IL-2 receptor

40% AR, adenosine deaminase deficiency

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12
Q

SCID clinical

A

absent Tcells, undetectable Ig, thymic dysplasia

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13
Q

Wiskott-Aldrich triad

A

ezcema, thrombocytopenia, immunodeficiency

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14
Q

Infections is W-A

A

encapsulated bacterial, pneumocystis, herpes

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15
Q

12% incidence of what in W-A

A

fatal malignancies

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16
Q

Immunodeficiency in W-A

A

Tcell and Bcell

17
Q

Ataxia-telangiectasia (lous-Barr) genetics

A

AR, ATM gene 11q

18
Q

Duncan disease genetics

A

X-linked lymphoproliferative disease
SH2D1A gene
SAP protein

19
Q

Duncan disease clinical

A

fatal immune response to EBV

hemophagocytic syndrome

20
Q

Integrin defiencines

A

LF-1 or MAC-1

periodontisi and delayed cord separation

21
Q

Jordan anomaly

A

vacuolization of leukocyte cytoplasm by fat

22
Q

classica complement deficineces (C1q, C2, C4) cause

A

autoimmune diseases (lupus)

23
Q

C2 or C3 deficiency

A

G+ encapsulated organisms

24
Q

C1 esterase inhibitor deficiency

A

hereditary angioedema

25
Q

Hereditary angioedema tests

A

CH50, C4, and C2 decreased during attacks

Between attacks, C2 normal

Clinical Pathology (59 decks)

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