Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Clinical Pathology > Chemistry 14 (Tumor markers) > Flashcards

Chemistry 14 (Tumor markers) Flashcards

1
Q

Hook effect

A

very high concentrations give falsely low result

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

free PSA and CA

A

decreased free and increased bound correlated with CA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

percent free PSA markedly affected by

A

protatic and urethral instrumentation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

pro-PSA

A

increased in CA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

non-neoplastic conditions with increased CEA

A

smoking, PUD, IBD, pancreatitis, hypothyroidism, biliary obstruction, cirrhosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

T1/2 of thyroglobulin

A

65hr

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

anti-thyroglobulin abs

A

10% of normal, >20% with thyroid CA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Tumor-associated trypsin inhibitor (TATI) is seen in

A 
mucinous ovarian CA
ureothelial CA
RCC
Gastric CA
Panc CA
pancreatitis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

CA-125 shows greatest sensitivity for

A

non-mucinous ovarian epithelial tumors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

____ is especially elevated in signet ring gastic CA

A

TATI

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

non-neoplastic conditions with increased CA125

A

pregnancy, fibrouds, benign ovarian cysts

PID, ascites, endometriosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

palpable adnexal mass + _____ = ______ for ovarian malig

A

+ CA125>65

= >95% PPV for ovarian malignancy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

CA125 and prognosis

A

preop >65 is unfavorable

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

CA27.29 and CA15-3

A

different epitopes of Brease CA assd MUC1 gene

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

better sens/spec between CA27.29 and CA15-3

A

CA 27.29

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

best marker for pancreato-biliary CA

A

CA19-9

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

CA19-9 also increased in

A

esophageal CA, pancretitis
cholestasis
cholangitis
cirrhosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

CA19-9 is not produced by people

A

who are Lewis Negative

19
Q

AFP synthesized by

A

fetal yolk sac, live, GI tract

20
Q

variant of gastric CA with increased AFP

A

hepatoid

21
Q

_____ use has been assd with low level increased HCG

A

marijuana

22
Q

beta2-microglobulin is independent pronositc factor in

A

myeloma

23
Q

forgut carcinoids produce

A

5-HT, catecholamines, 5-hydroxytryptophane

24
Q

midgut carcinoids produce

A

only serotonin

25
Q

hindgut carcinooids produce

A

usually are non-secretory

somes produce HCG

26
Q

what is metabolite of serotonin

A

5-HIAA

27
Q

____ may be most accurate marker for detection of carcinoid tumors

A

platelet serotonin

28
Q

increased chomogranini seen in

A

pheochromocytoma
carcinoid
islet cell tumors
small cell CA

29
Q

calcitonin increased in

A 
medullary thyroid
hashimoto
small cell
breast CA
chronic renal failure
zollinger-ellison syndrome
30
Q

marker also increased in medullary ca

A

CEA

31
Q

pheochromocytomas usually produce

A

epinephrine and norepinephrine

32
Q

extra-adrenal paragangiomas usually produce

A

only norepinephrine

33
Q

metabolite or normetanephrine

A

VMA

34
Q

metabolism of epinephrine

A

made into metanephrine, then sulfated or conjugated and excreted in urine or metabolised into VMA

35
Q

most accurate test for initial screening of paraganglioma/pheo

A

free plasma metanephrine

36
Q

____ elevated in neuroblastoma

A

urine VMA and HVA

37
Q

HVA is final metabolic product of

A

DOPA and dopamine

38
Q

VMA is final metabolic product of

A

epinephrine and norepinephrine

39
Q

poorly diff neuroblastomas make more ___ than ___

A

HVA than VMA

decreased VMA/HVA is bad

40
Q

increased levels of NMP22 have been seen in

A

urothelial CA

41
Q

FISH for aneuploidy of ____ in urothelial CA

A

3,7,9,17

42
Q

PCA3 is expressed in

A

prostativ glandular epithelium

encodes protein DD3

43
Q

DD3 overexpressed in

A

95% of prostate CA

44
Q

urine obtained after prostatic massage is tested for

A

DD3 RNA transcripts

Clinical Pathology (59 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions