Coag 4 Flashcards
GP Ib/V/IX (CD42) is receptor for what?
vWF
GP IIb/IIIa (CD41) is receptor for what?
fibrinogen
CD61 =
GP IIIa
GP Ia/IIa is receptor for what?
collagen
False + anti-cardiolipin caused by
syphilis
Q-fever
HIV
anti-Xa used to monitor
heparin
LMWH
danaparoid
causes of acquired AT deficiency
nephrotic syndrome L-asparaginase treatment liver failre DIC thrombosis
Prothrombin variant
20210A
seen in the Dutch
PF1 and 2 are
markers of prothrombin activation/in vivo thrombosis
____ is more sensitive to common pathway deficiencies than ___
PT than PTT
TT and RT prolongation caused by
afibrinogenemia
amyloidosis
low-dose ristocetin cofactor assay is used to detect type___ vWD
2B and plt-type
both show hyperaggregation
prenatal exposure to _____ or ____ may cause Vit K deficiency
phenytoid or phenobarbital
plt storage disorders with oculocutaneous albinism
Hermansky-Pudlak
Chediak-Higashi
storage pool defect seen in Puerto Ricans
Hermansky-Pudlak
Weibel-Palade bodies
where vWF is stored in endothelial cells
quinidine induced thrombocytopenia
responsible antigen is GP IX (of GP Ib/V/IX)
T1/2 of F8
12hr
Heterozygous deficiency of ___ may cause bleeding symptoms
F11
very increased PTT with no bleeding
prekallikren (Factor 12) deficiency
most common inherited combined factor deficiencies
5 and 8
T1/2 of F7
2-5 hr
T1/2 of protein C
6-8 hr
unable to achieve therapeutic response to heparin
antithrombin deficiency
syndrome 2-10d postpartum of fever, chest pain, pleural effusion, pulmonary infiltrates, cardiomyopathy, and ventricular arrhythmias may be caused by
Anti-cardiolipin antibodies
Wein-Penzing defect
deficiency in lipoxygenase pathway leading to early MI
T1/2 of prothrombin
96 hr
