Coag 4

Question 1

GP Ib/V/IX (CD42) is receptor for what?

Answer 1

vWF

Question 2

GP IIb/IIIa (CD41) is receptor for what?

Answer 2

fibrinogen

Question 3

CD61 =

Answer 3

GP IIIa

Question 4

GP Ia/IIa is receptor for what?

Answer 4

collagen

Question 5

False + anti-cardiolipin caused by

Answer 5

syphilis
Q-fever
HIV

Question 6

anti-Xa used to monitor

Answer 6

heparin
LMWH
danaparoid

Question 7

causes of acquired AT deficiency

Answer 7

nephrotic syndrome
L-asparaginase treatment
liver failre
DIC
thrombosis

Question 8

Prothrombin variant

Answer 8

20210A

seen in the Dutch

Question 9

PF1 and 2 are

Answer 9

markers of prothrombin activation/in vivo thrombosis

Question 10

____ is more sensitive to common pathway deficiencies than ___

Answer 10

PT than PTT

Question 11

TT and RT prolongation caused by

Answer 11

afibrinogenemia

amyloidosis

Question 12

low-dose ristocetin cofactor assay is used to detect type___ vWD

Answer 12

2B and plt-type

both show hyperaggregation

Question 13

prenatal exposure to _____ or ____ may cause Vit K deficiency

Answer 13

phenytoid or phenobarbital

Question 14

plt storage disorders with oculocutaneous albinism

Answer 14

Hermansky-Pudlak

Chediak-Higashi

Question 15

storage pool defect seen in Puerto Ricans

Answer 15

Hermansky-Pudlak

Question 16

Weibel-Palade bodies

Answer 16

where vWF is stored in endothelial cells

Question 17

quinidine induced thrombocytopenia

Answer 17

responsible antigen is GP IX (of GP Ib/V/IX)

Question 18

T1/2 of F8

Answer 18

12hr

Question 19

Heterozygous deficiency of ___ may cause bleeding symptoms

Answer 19

F11

Question 20

very increased PTT with no bleeding

Answer 20

prekallikren (Factor 12) deficiency

Question 21

most common inherited combined factor deficiencies

Answer 21

5 and 8

Question 22

T1/2 of F7

Answer 22

2-5 hr

Question 23

T1/2 of protein C

Answer 23

6-8 hr

Question 24

unable to achieve therapeutic response to heparin

Answer 24

antithrombin deficiency

Question 25

syndrome 2-10d postpartum of fever, chest pain, pleural effusion, pulmonary infiltrates, cardiomyopathy, and ventricular arrhythmias may be caused by

Answer 25

Anti-cardiolipin antibodies

Question 26

Wein-Penzing defect

Answer 26

deficiency in lipoxygenase pathway leading to early MI

Question 27

T1/2 of prothrombin

Answer 27

96 hr