Chemistry 7 (Renal)

Question 1

BUN always ___ the GFR because

Answer 1

slightly underestimates (even more in hypovolemia)
due to partial resorption of BUN in tubuels

Question 2

Azotemia =

Answer 2

increased BUN

Question 3

Jaffe reaction to meausre

Answer 3

creatinine concentration

Question 4

Creatinine always ___ the GFR due to

Answer 4

slightly overestimates

due to secretion of creatinine

Question 5

Creatinine clearance =

Answer 5

Urine creatinine x (urine vol/plasma creatinine)

Question 6

MDRD equation includes

Answer 6

serum creat, age, sex, race

Question 7

normal BUN/Cr

Answer 7

10:1

Question 8

intrarenal dz effect on BUN/Cr

Answer 8

ratio maintained

Question 9

Increased BUN/Cr ratio suggests

Answer 9

prerenal or postrenal

Question 10

decreased BUN/Cr ratio suggests

Answer 10

protein insufficiency, severe liver dz

Question 11

Cystatin C

Answer 11

freely filtered, independenly assd with cardiovascular events

Question 12

normal proteinuria

Answer 12

<150mg/day

Question 13

lower limit of detection for urine protein assay

Answer 13

3mg/dL

Question 14

good test for proteinuria other than 24 hr urine

Answer 14

Urine protein:creatinine ratio

Question 15

urine dipstick is sensitive to

Answer 15

albumin only

LOD 18mg/dL

Question 16

their presence in urine suggests tubular dysfunction

Answer 16

Beta2-microglobulin

lysozyme

Question 17

2 definitions of CKD

Answer 17

GFR<60

albuminuria x3mo

Question 18

stages of CKD

Answer 18

1= albuminuria with normal GFR
2=mild decreased GFR
3=mod decreased GFR
4=severe decreased GFR
5=GFR<15

Question 19

BUN/Cr in prerenal and renal ARF

Answer 19

prerenal >20:1

renal <20:1

Question 20

FE Na in prerenal and renal ARF

Answer 20

Prerenal less than 1

Renal greater than 2

Question 21

FE urea in prerenal and renal ARF

Answer 21

Prerenal less than 35

Renal greater than 35

Question 22

most common causes of ATn

Answer 22

ischemia and nephrotoxins

Question 23

indications for dialysis

Answer 23

refractory vol overload
hyperkalemia
metabolic acidosis
end organ damage (pleural effusions)
BUN > 100

Question 24

non-oliguric renal failure rarely seen in

Answer 24

pre-renal

Question 25

UA findings in tubulointerstitial nephritis

Answer 25

WBC casts and eos

Question 26

most common cause of RF in cirrhosis

Answer 26

spontaneous bacterial peritonitis

Question 27

cirrhosis can lead to ____-like changes in kidney

Answer 27

IgA-like nephropathy

Question 28

hypatorenal syndrome thought to be due to

Answer 28

dysregulation of renal blood flow