Chemistry 7 (Renal) Flashcards
BUN always ___ the GFR because
slightly underestimates (even more in hypovolemia) due to partial resorption of BUN in tubuels
Azotemia =
increased BUN
Jaffe reaction to meausre
creatinine concentration
Creatinine always ___ the GFR due to
slightly overestimates
due to secretion of creatinine
Creatinine clearance =
Urine creatinine x (urine vol/plasma creatinine)
MDRD equation includes
serum creat, age, sex, race
normal BUN/Cr
10:1
intrarenal dz effect on BUN/Cr
ratio maintained
Increased BUN/Cr ratio suggests
prerenal or postrenal
decreased BUN/Cr ratio suggests
protein insufficiency, severe liver dz
Cystatin C
freely filtered, independenly assd with cardiovascular events
normal proteinuria
<150mg/day
lower limit of detection for urine protein assay
3mg/dL
good test for proteinuria other than 24 hr urine
Urine protein:creatinine ratio
urine dipstick is sensitive to
albumin only
LOD 18mg/dL
their presence in urine suggests tubular dysfunction
Beta2-microglobulin
lysozyme
2 definitions of CKD
GFR<60
albuminuria x3mo
stages of CKD
1= albuminuria with normal GFR 2=mild decreased GFR 3=mod decreased GFR 4=severe decreased GFR 5=GFR<15
BUN/Cr in prerenal and renal ARF
prerenal >20:1
renal <20:1
FE Na in prerenal and renal ARF
Prerenal less than 1
Renal greater than 2
FE urea in prerenal and renal ARF
Prerenal less than 35
Renal greater than 35
most common causes of ATn
ischemia and nephrotoxins
indications for dialysis
refractory vol overload hyperkalemia metabolic acidosis end organ damage (pleural effusions) BUN > 100
non-oliguric renal failure rarely seen in
pre-renal
UA findings in tubulointerstitial nephritis
WBC casts and eos
most common cause of RF in cirrhosis
spontaneous bacterial peritonitis
cirrhosis can lead to ____-like changes in kidney
IgA-like nephropathy
hypatorenal syndrome thought to be due to
dysregulation of renal blood flow
