Heme Path 4 Flashcards
definition of prolymphoctic leukemia
> 55% prolyphocytes
prolymphocyte morphology
prominent nucleolus, moderate eccentric cytoplasm
phenotype of prolymphocytic leukemia
bright 20, CD11c, sIg, 22, FMC7
translocaiton in lymphoplasmacytic leukemia
t(9;14)
phenotype of lymphoplasmacytic leukemai
20, 19, 38, s/cIg, (+/- 5 and 43)
BCL6 gene location
3q
BCL6 overexpressed in (3)
FL, DLBCL, Burkitt
BCL6 normally expressed in
geminal center Bcell
Large Bcell lymphoma with predilection to involve marrow at diagnosis
Tcell rich large cell lymphoma
Primary effusion lympmhoma assd virus
HHV-8 in HIV pts
Primary effusion lymphpma phenotype
CD30, CD38, CD138, EMA (+/- CD45)
Virus assd with lymphomatoid granulomatosis
EBV
Histology of lymphomatoid granulomatosis
vasculitic, Tcells, PCs, histiocytes in lung
AML frequently showing dim CD19
t(8;21)
phenotype of ALL with t(1;19)
CD19, CD9, CD10 +
CD34, CD20-
favorable ALL cytogenetics
hyperdiploid, t(12;21)
most common ALL abnormality
t(9;22) poor prognosis
Size of t(9;22) protein in ALL
190kd (minor breakpoint)
size of t(9;22) protien in CML
210kd (major breakpoint
poor prognosis in ALL
t(9;22)
t(1;19)
11q (MLL)
hypodiploid
ALL with t(4;11) phenotype
CD15+, CD10-
Most specific AML marker
CD117
90% of IgD myelomas are ____ restricted:
lambda
most common translocaiton in myeloma
t(11;14) cyclin D1
poor prognosis in myeloma
t(4;14), t(14;16), del17p
paraprotein assd with plasma cell leukemia
IgE
Franklin Disease
heavy chain disease
most common is alpha
associated with immunoproliferative small bowel disease
“cloverleaf” nuclei
peripheral tcell lymphoma, Adult t cell lymphoma
Lennert like lymphpma
Lymphoepithliod/lymphohistiocytic variant of peripheral Tcell lymphoma
chromosomal alteration in Lennert like lymphoma
trisomy 3
