Heme Path 4

Question 1

definition of prolymphoctic leukemia

Answer 1

> 55% prolyphocytes

Question 2

prolymphocyte morphology

Answer 2

prominent nucleolus, moderate eccentric cytoplasm

Question 3

phenotype of prolymphocytic leukemia

Answer 3

bright 20, CD11c, sIg, 22, FMC7

Question 4

translocaiton in lymphoplasmacytic leukemia

Answer 4

t(9;14)

Question 5

phenotype of lymphoplasmacytic leukemai

Answer 5

20, 19, 38, s/cIg, (+/- 5 and 43)

Question 6

BCL6 gene location

Answer 6

3q

Question 7

BCL6 overexpressed in (3)

Answer 7

FL, DLBCL, Burkitt

Question 8

BCL6 normally expressed in

Answer 8

geminal center Bcell

Question 9

Large Bcell lymphoma with predilection to involve marrow at diagnosis

Answer 9

Tcell rich large cell lymphoma

Question 10

Primary effusion lympmhoma assd virus

Answer 10

HHV-8 in HIV pts

Question 11

Primary effusion lymphpma phenotype

Answer 11

CD30, CD38, CD138, EMA (+/- CD45)

Question 12

Virus assd with lymphomatoid granulomatosis

Answer 12

EBV

Question 13

Histology of lymphomatoid granulomatosis

Answer 13

vasculitic, Tcells, PCs, histiocytes in lung

Question 14

AML frequently showing dim CD19

Answer 14

t(8;21)

Question 15

phenotype of ALL with t(1;19)

Answer 15

CD19, CD9, CD10 +

CD34, CD20-

Question 16

favorable ALL cytogenetics

Answer 16

hyperdiploid, t(12;21)

Question 17

most common ALL abnormality

Answer 17

t(9;22) poor prognosis

Question 18

Size of t(9;22) protein in ALL

Answer 18

190kd (minor breakpoint)

Question 19

size of t(9;22) protien in CML

Answer 19

210kd (major breakpoint

Question 20

poor prognosis in ALL

Answer 20

t(9;22)
t(1;19)
11q (MLL)
hypodiploid

Question 21

ALL with t(4;11) phenotype

Answer 21

CD15+, CD10-

Question 22

Most specific AML marker

Answer 22

CD117

Question 23

90% of IgD myelomas are ____ restricted:

Answer 23

lambda

Question 24

most common translocaiton in myeloma

Answer 24

t(11;14) cyclin D1

Question 25

poor prognosis in myeloma

Answer 25

t(4;14), t(14;16), del17p

Question 26

paraprotein assd with plasma cell leukemia

Answer 26

IgE

Question 27

Franklin Disease

Answer 27

heavy chain disease
most common is alpha
associated with immunoproliferative small bowel disease

Question 28

“cloverleaf” nuclei

Answer 28

peripheral tcell lymphoma, Adult t cell lymphoma

Question 29

Lennert like lymphpma

Answer 29

Lymphoepithliod/lymphohistiocytic variant of peripheral Tcell lymphoma

Question 30

chromosomal alteration in Lennert like lymphoma

Answer 30

trisomy 3