Chemistry 9 (Drugs of Abuse)

Question 1

Volume of distribution =

Answer 1

Dose/concentration

Question 2

usual method for confirmation of +drug screen

Answer 2

gas chromatography/mass spec

Question 3

key metabolite of cocaine (and T1/2)

Answer 3

benzoyl ecgonine, methyl ester

1 hr

Question 4

Metabolite of heroine and T1/2

Answer 4

6-acetylmorphine

3min

Question 5

metabolite of amphetamines and T1/2

Answer 5

norepi/phenylacetone

30min

Question 6

metabolite of PCP

Answer 6

hydroxlyated and glucuronated drug

Question 7

meatbolite of Cannabis and T1/2

Answer 7

delta-9-THC-COOH

8hr

Question 8

urine suspicious for tampering if pH

Answer 8

< 4.5

or >8.0

Question 9

urine suspicious for tampering if specific gravity___ or creatinine____

Answer 9

< 1.005

< 5mg/dL

Question 10

acute cocaine tox sx

Answer 10

sympathetic activation, hyperthemia

HTN, arrhythmia

Question 11

acute opiate tox sx

Answer 11

pinpoint pupils, constipation, bradycardia,

hypotension, AMS, resp arrest

Question 12

treatment for opiate symptoms

Answer 12

naloxone or nalmefene

Question 13

opiate withdrawal symptoms

Answer 13

lacrimation, rhinorrhea, diaphoresis, dilated pupils, tachycardia, irritability

Question 14

tx for opiate withdrawal

Answer 14

methadone or clonidine

Question 15

opiate that causes cardiac conduction abnormalities and seizures

Answer 15

propoxyphene

Question 16

barbiturates act through

Answer 16

GABA facilitation

Question 17

barbiturate tox sx

Answer 17

decreased consciousness, resp suppression (via medulla), AMS, hypotension, pulmonary edema, hypothermia

Question 18

amphetamines release ____. long term use may lead to____

Answer 18

dopamine

irreversible Parkinsonian syndrome

Question 19

acute acetaminophen intoxication

Answer 19

hyperpnea, hyperthermia, tachycardia, HTN, anxiety, AMS, seizure

Question 20

PCP effects are through

Answer 20

blocking catecholamine reuptake

Question 21

clue to PCP use

Answer 21

hoizontal nystagmus

Question 22

severe PCP intox

Answer 22

hypoglycemia, hypotension, bradycardia, hypopnea, rhabdomyolysis, AMS, seizure, hyperthermia

Question 23

for EtOH level, collect in____

Answer 23

Sodium fluoride or Potassium oxalate

Question 24

GGT requires how much time to be increased, then return to normal

Answer 24

4drinks per day x 4 weeks to increase

4weeks to return to normal

Question 25

carbohydrate deficient transferrin increases after how long of heavy drinking

Answer 25

1-2wks

Question 26

MCV is ___ in heavy EtOH use

Answer 26

increased after 4-8wks