Chemistry 13 (Lipids and Carbs) Flashcards
Apolopoproteins in chylomicrons
B-48, A-1, C, E
function of chylomicrons
transport lipid from enterocytes to other cells
endocytosed by apolipoprotein E
apolipoprotein and function of VLDL
B-100, C, E
triglycerides to somatic cells
enzymes that hydrolyzes TG in VLDL
lipoprotein lipase
Apolipoprotein B-100 present in
LDL, IDL, VLDL
HDL apolipoprotein
A-1, C, E
Function of LDL
transport cholesterol to somatic cells
lecithin cholesterol acyl transferase is present on
HDL
VLDL calculation
TG/5 (fails if TG>400)
beta-VLDL present in
type III dyslipidemia
firedewald equation
LDL=Tchol-HDL-TG/5
fiedewald not valid if
TG>400
chylomicroms present
type III dyspilidemia
gold standard for LDL measurement
ultracentrifugation
lipoprotein electrophoresis bands
Chylomicrons don’t move from application point
HDL = alpha
VLDL = pre-beta
LDL = beta
type I dyslipidemia
incresed chylommicrons
types IIa and IIb dyslipidemia
increased LDL
increased LDL and VLDL
type III dyslipidemia
increased IDL
type V dyslipidemia
increased VLDL and chylomicrons
apo B is major apolipoprotein of
LDL and VLDL
tendinous xanthomas present when
cholest and TG elevated
lipid disorders featuring pancreatitis
familial LPL deficiency
apo C-II deficiency
hypertriglyceridemia
lipid disorders with very high cholest and TG
apolipoprotein E def
familial dysbetalipoproteinemia
familial hypercholesterolemia deficiency
deficiency of LDL receptor
Tangier dz
AR
absent HDL