Coag 1 (vWF)

Question 1

vWF normally binds to

Answer 1

Factor 8

Question 2

ADAMTS-13 deficiency

Answer 2

TTP

Question 3

What test measures the activity of vWF

Answer 3

vWF:Rcof

Question 4

vWD with all sizes multimers present but decreased

Answer 4

type 1

Question 5

vWD with no large or medium mulitmers

Answer 5

Type 2a

Question 6

vWD with no large mulitmers

Answer 6

Type 2b

Question 7

vWD with almost no mulitmers

Answer 7

Type 3

Question 8

most common type of vWD

Answer 8

type 1

Question 9

Type of vWD treated with DDAVP

Answer 9

type 1

Question 10

Multimers in type 2a vWD

Answer 10

decreased large and medium

Question 11

Type 1 vWD antigen and cofactor tests

Answer 11

normal Ag (normal quantify)
decreased vWF:Rcof (decreased quality)

Question 12

vWD with increased affinity of HMW multimers to GP1b

Answer 12

type 2b

Question 13

RIPA in type 2b vWD

Answer 13

increased

Question 14

Factor 8 is also low in vWD type

Answer 14

type 3

Question 15

vWD 2M defect

Answer 15

GP1b binding

Question 16

antigen level and vWF:Rcof in type 2M

Answer 16

normal antigen level

decreased activity

Question 17

type of vWD where binding to F8 is the problem

Answer 17

type 2N

Question 18

Labs in vWD type 2N

Answer 18

normal Ag level, normal ristocetin cofactor, normal multimers

Question 19

defect in platelet type vWD

Answer 19

increased affinity of GP1b for vWF

Question 20

vWD with abnormal RIPA

Answer 20

2b and platelet type

Question 21

differentiate between type 2b and platelet type

Answer 21

large multimers present in platelet type

platelet type will aggregate with cryoprecipitate

Question 22

normal vWF activities by blood group

Answer 22

O 75%
A (100%)
B or AB (120%)

Question 23

newborn vWF activity

Answer 23

higher than adult

Question 24

type of vWD to NOT give ddavp to

Answer 24

type 2b

Question 25

vWD type 2b mutation

Answer 25

gain of function point mutation in GP1b binding domain of vWF

Question 26

plt type vWD mutation

Answer 26

mutation of plt GP1b protein with enhanced vWF binding

Question 27

both plt type and 2b clinically cause

Answer 27

clearance ofplts and HMW multimers

Question 28

type 2M vWD mechanism

Answer 28

prevents binding of vWF tp GP 1b | opp of 2b and plt type

Question 29

Type 2N vWD mechanism

Answer 29

prevents binding of vWF to F8

Question 30

vWD that looks like hemophilia

Answer 30

2N and 3

Question 31

best test to distinguish between 2B and plt-type

Answer 31

in plt-type, plts aggregate with cryoprecipitate

Question 32

Type Vicenza vWD

Answer 32

increased clearance | still see large multimers on multimer analysis